MICROBIOLOGICAL AND IMMUNOLOGICAL FEATURES OF MULTIFORM EXUDATIVE ERYTHEMA OF THE MOUTH
Keywords:
Erythema multiforme, local therapy, optimization, comparative study, photodynamic therapy, oral mucosaAbstract
This study aimed to optimize the treatment of patients with exudative erythema multiforme (EM) by comparing traditional therapy with the addition of laser irradiation using photodynamic therapy (PDT). A total of 64 patients with EM participated in the study, and their clinical courses and risk factors for oral mucosa lesions were analyzed. The main group received local and general treatments, including lidocaine gel, chlorhexidine solution, and PDT, while the comparison group received traditional treatment. The effectiveness of therapy was assessed using a 3-point system based on subjective sensations and clinical symptoms. No side effects or complications were identified during the treatments. The results showed that patients in the main group experienced a significant reduction in clinical manifestations of EM compared to those in the comparison group. The average intensity of symptoms decreased by nearly 2 times on the 5th day and more than 11 times on the 15th day in the main group, whereas the reduction was 4 times and 8 times, respectively, in the comparison group. These findings suggest that the addition of laser irradiation using PDT to the treatment regimen may improve the outcomes for patients with exudative erythema multiforme. Further research is warranted to validate these results and explore the long-term effects of this approach.
References
Aurelian L, Ono F, Burnett J. Herpes simplex virus (HSV)-associated erythema multiforme (HAEM): a viral disease with an autoimmune component. Dermatol Online J 2003 ; 9 :1 . [ PubMed ] [ Google Scholar ]
Ayangco L, Rogers RS. Oral manifestations of EM. Dermatol Clin 2003 ;21:195 –205. [ PubMed ] [ Google Scholar ]
Baillis B., Maize JC Treatment of Recurrent Erythema Multiforme with Adalimumab as Monotherapy. JAAD Case Rep. 2017 ;3:95 –97. doi : 10.1016/j.jdcr.2016.11.009. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ]
Chen CW, Tsai TF, Chen YF, Hung CM Persistent Erythema Multiforme Treated with Thalidomide. Am. J. Clin . Dermatol . 2008 ;9:123 –127. doi : 10.2165/00128071-200809020- 00006. [ PubMed ] [ CrossRef ] [ Google Scholar ]
Demirbaş A., Elmas O.F., Atasoy M., Türsen O., Lotti T. Dermatologic Therapy. John Wiley & Sons ; Hoboken, NJ, USA: 2020. A Case of Erythema Multiforme Major in a Patient with COVID 19: The Role of Corticosteroid Treatment. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ]
Firoozeh S, Ajit A, Christopher Z, Michele W. Erythema multiforme a review of epidemiology, pathogenesis, clinical features, and treatment. Dent Clin N Am . 2013 ;57:583 -596. [ PubMed ] [ Google Scholar ]
Kamilov H.P, Takhirova K.A, Nomurodova F The prevalence and course of multiform exudative erythema of the oral cavity Actual problems of dentistry and maxillofacial surgery, 2022 [ Google Scholar ]
