EFFICIENCY OF IMIQUIMOD IN TREATMENT OF CONDYLOMA ACUMINATA

Abstract

Human papillomavirus (HPV) anogenital infections are the most prevalent viral sexually transmitted disease (STD) among young people worldwide. Treatments that have demonstrated good to moderate efficacy in eliminating genital warts include patient-applied topical medications (podophyllotoxin, interferon (IFN)), as well as ablative or cytodestructive techniques. Recurrence rate of condyloma acuminata are an issue, study was performed to evaluate better therapy. How laser treatment for external anogenital warts affected the continued clearance of treated lesions and the safety of topical Imiquimod used by the patient. Asses 2 type of treatment: monotherapy by laser with combined therapy - after laser treatment of visible external anogenital warts, the ablated region(s) were treated with Imiquimod 5% cream, in the following order: three times per week over the course of 12 weeks, starting once when the wound healing process was considered complete, followed by a six-month observation period for the assessment of sustained clearance of treated lesions. 28 (37.3%) of the patients in the first group experienced relapses during the course of the study, according to a correlative assessment of the clinical competence of the treatment. The recurrence rate within 6 months was only 9 (7.2%) and clinical recovery without a recurrence was 116 (92.8%) in group II patients, which is a statistically significant (p≤0.05) reduction in the relapse rate with the complex method therapy.