IMPACT OF SLEEVE GASTRECTOMY WITH BIPARTITION ON GLYCEMIC CONTROL IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
Keywords:
type 2 diabetes mellitus, sleeve gastrectomy, bipartition, glycemic control, metabolic surgery, HbA1cAbstract
Relevance. Obesity-associated type 2 diabetes mellitus (T2DM) remains a major global health problem. Conventional medical therapy often fails to achieve sustained glycemic control. Therefore, metabolic surgery, particularly sleeve gastrectomy with bipartition (SG-B), has emerged as a promising approach for improving glucose metabolism.
Purpose. To evaluate the impact of sleeve gastrectomy with bipartition on glycemic control in patients with type 2 diabetes mellitus.
Materials and methods. The study included patients with obesity and T2DM who underwent SG-B. Glycemic parameters, including fasting plasma glucose and HbA1c levels, were assessed preoperatively and at 3, 6, and 12 months postoperatively. Statistical analysis was performed to evaluate changes over time.
Results. A significant improvement in glycemic control was observed after surgery. Both fasting glucose and HbA1c levels demonstrated a statistically significant decrease. Additionally, a reduction or complete discontinuation of antidiabetic medications was noted in a substantial proportion of patients.
Conclusion. Sleeve gastrectomy with bipartition is an effective metabolic surgical procedure for improving glycemic control in patients with type 2 diabetes mellitus. This technique contributes to better diabetes management and reduces pharmacological dependence.
References
American Diabetes Association. Standards of medical care in diabetes — 2023. Diabetes Care. 2023;46(Suppl 1):S1–S291. doi:10.2337/dc23-Sint.
Angrisani L, Santonicola A, Iovino P, et al. Bariatric surgery worldwide 2018. Obesity Surgery. 2020;30(10):1–12. doi:10.1007/s11695-020-04707-3.
Courcoulas AP, Yanovski SZ, Bonds D, et al. Long-term outcomes of bariatric surgery: a National Institutes of Health symposium. JAMA Surgery. 2014;149(12):1323–1329. doi:10.1001/jamasurg.2014.2440.
Cummings DE, Overduin J. Gastrointestinal regulation of food intake. Journal of Clinical Investigation. 2007;117(1):13–23. doi:10.1172/JCI30227.
DePaula AL, Stival AR, DePaula CC, et al. Sleeve gastrectomy with ileal interposition (“two-segment transit”): metabolic effects and diabetes control. Surgery for Obesity and Related Diseases. 2015;11(5):1123–1130. doi:10.1016/j.soard.2015.01.012.
Mingrone G, Panunzi S, De Gaetano A, et al. Bariatric–metabolic surgery versus conventional medical treatment in obese patients with type 2 diabetes: 5-year follow-up. The Lancet. 2015;386(9997):964–973. doi:10.1016/S0140-6736(15)00075-6.
Rubino F, Nathan DM, Eckel RH, et al. Metabolic surgery in the treatment algorithm for type 2 diabetes: a joint statement by international diabetes organizations. Diabetes Care. 2016;39(6):861–877. doi:10.2337/dc16-0236.
Schauer PR, Bhatt DL, Kirwan JP, et al. Bariatric surgery versus intensive medical therapy for diabetes — 5-year outcomes. New England Journal of Medicine. 2017;376:641–651. doi:10.1056/NEJMoa1600869.
World Health Organization. Global report on obesity: epidemiology, burden and prevention strategies. Geneva: WHO; 2022.
World Health Organization. Obesity and overweight. WHO Fact Sheet. Geneva: World Health Organization; 2023.