MODERN ASPECTS OF DIAGNOSING BENIGN GYNECOLOGICAL DISORDERS IN GIRLS AND ADOLESCENTS WITH MÜLLERIAN DUCT ANOMALIES
Keywords:
Müllerian duct anomalies; adolescent girls; benign gynecological disorders; diagnosis; ultrasonography; magnetic resonance imaging; reproductive health; congenital anomalies; pediatric gynecologyAbstract
Congenital Müllerian duct anomalies represent one of the most complex developmental disorders of the female reproductive tract and are frequently associated with benign gynecological diseases during childhood and adolescence. Altered pelvic anatomy often leads to atypical clinical manifestations, delayed diagnosis, and an increased risk of long-term reproductive complications. Despite advances in imaging techniques, comprehensive diagnostic approaches for this patient population remain insufficiently standardized. Objective. To evaluate the diagnostic value of current clinical, laboratory, and imaging methods in detecting benign gynecological disorders among girls and adolescents with Müllerian duct anomalies and to identify the most informative diagnostic criteria for early disease detection. Materials and Methods. The study included 68 girls aged 12–18 years diagnosed with Müllerian duct anomalies. The main group consisted of 46 patients with concomitant benign gynecological disorders, while the comparison group included 22 patients without associated benign pathology. All participants underwent clinical examination, pelvic ultrasonography, magnetic resonance imaging when indicated, laboratory investigations, and multidisciplinary consultations. Statistical analysis was performed using standard biomedical statistical methods.
References
American Society for Reproductive Medicine (ASRM). Müllerian Anomalies Classification 2021. Fertility and Sterility. 2021;116(5):1238–1252.
Grimbizis G.F., Di Spiezio Sardo A., Saravelos S.H., et al. The ESHRE/ESGE consensus on the classification of female genital tract congenital anomalies. Human Reproduction. 2013;28(8):2032–2044.
Chan Y.Y., Jayaprakasan K., Zamora J., et al. The prevalence of congenital uterine anomalies in unselected and high-risk populations: a systematic review. Human Reproduction Update. 2011;17(6):761–771.
Ludwin A., Ludwin I. Comparison of the ESHRE–ESGE and ASRM classifications of Müllerian duct anomalies. Journal of Minimally Invasive Gynecology. 2015;22(7):1238–1245.
ACOG Committee Opinion No. 728. Müllerian Agenesis: Diagnosis, Management and Treatment. Obstetrics & Gynecology. 2018;131–e42.
Oppelt P., Renner S.P., Kellermann A., et al. Clinical aspects of Mayer–Rokitansky–Küster–Hauser syndrome. Fertility and Sterility. 2006;86(5):1432–1436.
Morcel K., Camborieux L., Guerrier D. Mayer–Rokitansky–Küster–Hauser syndrome. Orphanet Journal of Rare Diseases. 2007;2:13.
Saravelos S.H., Cocksedge K.A., Li T.C. Prevalence and diagnosis of congenital uterine anomalies in women with reproductive failure. Human Reproduction Update. 2008;14(5):415–429.
Rizaev J. A., Ashirov Z. F., Toshev S. U., Islamov N. H., Salamova L. A. [et al.]. Medical and organizational measures to improve the provision of medical care in the dermatovenerology profile // International Journal of Current Research and Review. – 2020. – Vol. 12, No. 24. – P. 120–122.
Ризаев Ж. А., Адилова Ш. Т., Пулатов О. А. Обоснование комплексной программы лечебно-профилактической стоматологической помощи населению Республики Узбекистан // Аспирант и соискатель. – 2009. – С. 73–74.
Alimdjanovich J. R., Ibragimovich A. K. Organization of monitoring of the quality of services provided for the prevention and fight against postpartum bleeding in women // Central Asian Journal of Medical and Natural Sciences. – 2021. – Vol. 2, No. 6. – P. 14–21.
Alimjanovich J. R., Agababyan L. R., Kamalov A. I. Prevention and treatment of postpartum hemorrhage // Central Asian Journal of Medical and Natural Sciences. – 2021. – Vol. 2, No. 4. – P. 204–209.
Practice Committee of the American Society for Reproductive Medicine. Uterine septum: evidence-based diagnosis and management. Fertility and Sterility. 2024;121(2):256–270.
ESHRE Guideline Group. Guideline on Female Genital Tract Congenital Anomalies. European Society of Human Reproduction and Embryology. 2023.
WHO. Adolescent Health. Geneva: World Health Organization; 2023.
FIGO Committee. Adolescent Gynecology: Good Clinical Practice Recommendations. International Journal of Gynecology & Obstetrics. 2022;159(Suppl.1):1–18.
Committee on Adolescent Health Care. Menstrual disorders in adolescents. Obstetrics & Gynecology. 2019;134–e83.
Laufer M.R., Goldstein D.P. Pediatric and Adolescent Gynecology. 7th ed. Philadelphia: Wolters Kluwer; 2023.
Emans S.J., Laufer M.R., Goldstein D.P. Pediatric and Adolescent Gynecology. 7th ed. Lippincott Williams & Wilkins; 2020.
