MODERN DYNAMICS OF SPREAD AND CLINICAL MANIFESTATIONS OF BACTERIAL INFECTIONS OF THE GASTROINTESTINAL TRACT

Authors

  • SHADJALILOVA Mukarram Salimdjanovna
  • XALILOVA Zuhra Telmanovna

Keywords:

children, diarrhea, intestinal infections, symptoms

Abstract

Acute intestinal infections (AI) have always been and remain to this day a complex health problem. The aim of the study was to determine the structure and clinical characteristics of bacterial intestinal infections in young children. A survey and observation of 260 children aged from 3 months to 3 years was carried out. General clinical, immunological, bacteriological, serological and static research methods were used. Clinical and laboratory studies conducted in children with bacterial intestinal infections revealed the presence of multidrug-resistant strains of salmonellosis (Salmonella typhimurium var. Сopengagen) in 63% of cases and 36% of Clostridi difficile cases. The incidence of dysentery and escherichiosis among children over one year of age is 2-3 times higher than among children under one year of age. In case of Salmonella and Shigella infections, the intestinal microbiocenosis was characterized by an association of microorganisms. The clinical course of bacterial intestinal infections in young children in modern conditions is determined by the dependence of the etiology of the pathogen, combined damage to parts of the gastrointestinal tract and the tendency to develop relapses of the disease.

References

Shadzhalilova, M. S., Sharopova, G. M., & Osipova, E. M. (2022). Comparative evaluation of the clinical course of acute diarrhea in children. Tibbiyotda yangi kun (New Day in Medicine), 2(40), 552–555. (in Russ).

Tadzhiev, B. M., Khudaiberdieva, C. K., & Akhrarova, A. R. (2023). Features of acute infectious diarrhea in children in the Republic of Uzbekistan. Science and Innovation International Scientific Journal, 2(5), 2024–2030.

Vernacchio, L., Vezina, R. M., Mitchell, A. A., Lesko, S. M., Plaut, A. G., & Acheson, D. W. (2006). Diarrhea in American infants and young children in the community setting: Incidence, clinical presentation, and microbiology. The Pediatric Infectious Disease Journal, 25 (1), 2–7. (in Russ).

Al-Asy, H. M., Gamal, R. M., Albaset, A. M. A., Elsanosy, M. G., & Mabrouk, M. M. (2017). New diagnostic biomarker in acute diarrhea due to bacterial infection in children. International Journal of Pediatrics and Adolescent Medicine, 4(2), 75–80.

Kasymov, I. A., Shadzhalilova, M. S., & Agzamova, T. A. (2016). Issues of clinical presentation, diagnosis, treatment, and prevention of acute dysentery. Extremum-Press.

Shadzhalilova, M. S. (2015). Analysis of clinical, epidemiological, and microbiological parameters of acute intestinal infections in children. Medical News (Belarus), (8), 60–62.

World Health Organization. (2013). Hospital care for children: Guidelines for the management of common childhood illnesses (pp. 76–90). Tashkent. (in Russ).

Zaitseva, N. V., Khmelevskaya, I. G., & Kalutsky, P. V. (2017). Clinical and immunological features of the course of viral diarrhea in children. Bulletin of Contemporary Clinical Medicine, 10 (2), 30–33. (in Russ).

Shadzhalilova, M. S., Sharopova, G. M., & Osipova, E. M. (2022). Comparative evaluation of the clinical course of acute diarrhea in children. Tibbiyotda yangi kun (New Day in Medicine), 2(40), 552–555. (in Russ).

Tadzhiev, B. M., Khudaiberdieva, C. K., & Akhrarova, A.R. (2023). Features of acute infectious diarrhea in children in the Republic of Uzbekistan. Science and Innovation International Scientific Journal, 2(5), 2024–2030.

Shadzhalilova, M. S., Khalilova, Z. T., & Osipova, E. M. (2023). Analysis of pro- and anti-inflammatory cytokines in certain acute diarrheal diseases. Journal of Infectology, 15(1), 190–191.

Shadzhalilova, M. S., & Khalilova, Z. T. (2024). Features of the clinical course and intestinal microbiocenosis in children with acute diarrhea. Journal of Infectology, 16 (2, Suppl. 1), 190–193. (in Russ).

Buribaeva, B. I., Shadzhalilova, M. S., Khalilova, Z. T., & Sharapova, G. M. (2024). Clinical and microbiological features of intestinal Escherichia coli infection in children. Science and Innovation International Scientific Journal. Series D, 3(3), 98–101.

Sharapova, G.M., Shadzhalilova, M. S., & Khairulina, A. Kh. (2025). Clinical characteristics and the status of certain cytokines in salmonellosis infection in children. Infektsiya, Immunitet va Farmakologiya, (3), 411–418. (in Russ).

Published

2026-05-06