BOLALAR SEREBRAL FALAJIDA BOTULINOTERAPIYAGA JAVOBNING INDIVIDUAL VARIATSIYALARI VA NEYROMUSHAK PLASTIKLIGI
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bolalar serebral falaji, botulinoterapiya, neyromushak plastikligi, EMG, spastiklik, GMFM, molekulyar mexanizmlar##article.abstract##
ANNOTATSIYA
Ushbu tadqiqotning maqsadi bolalar serebral falajida (BSF) botulinoterapiyaga klinik va elektrofiziologik javobning individual variativligini belgilovchi omillar hamda neyromushak plastikligi mexanizmlarini o‘rganishdan iborat. Botulin toksini A turini yuborishdan oldin va keyin tizimli, to‘qima va molekulyar darajalardagi o‘zgarishlarni baholash orqali kompleks klinik-nevrologik, funksional va elektromiografik tahlil o‘tkazildi. Olingan natijalar spastiklikni davolashning an’anaviy usullari bilan solishtirildi. Tadqiqot natijalari botulinoterapiya samaradorligi nafaqat inʼeksiya dozalari va joylashuviga, balki neyromushak plastikligining saqlangan darajasi, bemorning yoshi, serebral falaj turi hamda harakat faolligi darajasiga ham bog‘liqligini ko‘rsatdi.
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