O'TKIR KORONAR SINDROMNING ERTA RIVOJLANISHI BILAN OG'RIGAN BEMORLARDA KORONAR ARTERYALARNING ATEROSKLEROTIK JAROHATLANISHI
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o'tkir koronar sindrom, genlar va irsiy omil##article.abstract##
Ko'pgina tadqiqotlar natijalariga ko'ra, ko'pchilik odamlar uchun irsiy yurak kasalligi xavfi atrof- muhit va turmush tarzi omillari bilan birgalikda va ular bilan birgalikda ta'sir qiluvchi ko'plab kichik ta'sirli genetik omillarning natijasidir. Genom-Wide Association Studies (GWAS) [1,10] da genomik assotsiatsiyalarning katta populyatsiyasini o'rganish natijasida SAPR bilan bog'liq umumiy genetik variantlar aniqlangan. Bir qator tadqiqotlar ADAMTS7 geni rs3825807, VEGF-A geni rs699947, CDKN2B geni rs2891168, CXCL12 geni rs1746048 va C8SH413 genining C8SH403 gen polimorfizmlari o'rtasidagi bog'liqlikni ko'rsatadi [3,9].
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