COMPARATIVE EVALUATION OF NEW OSTEOPLASTIC MATERIALS BASED ON THE RESULTS OF ACUTE TOXICITY STUDIES
Keywords:
osteoplastic material, median lethal dose, acute toxicityAbstract
Three series of experiments were carried out and lethal doses of the new osteoplastic material 47.5 V were determined by the intraperitoneal and intragastric injection of the material to laboratory animals. A comparative evaluation with Bioactive glass BG-1D was also carried out. It was found that the LD50 of 47,5B was 4274.51:4770.58 mg/kg for intragastric injection and 2358.31:2895.65 mg/kg for intraperitoneal injection to rats. In animals getting Bioactive glass BG-1D, these indicators changed slightly, amounting to 3439.04:3810.53 mg/kg and 1732.77:2730.93 mg/kg, respectively. Thus, according to the classification of substances according to the degree of toxicity, these materials can be attributed to practically non-toxic substances (according to the results of intraperitoneal injection of the material suspension to rats and mice) and low-toxic substances (according to the results of intragastric injection of the material suspension to rats).
References
Khabilov N. L., Ziyadullayeva N. S., Khabilov D. N., Buronov B. T. Comparative analysis of biomaterials intended for osteoarthritis. Journal of Medicine Innovations. 2021; 1: P. 72-77/
Akbarov A. N., Ziyadullayeva N. S., Khabilov B. N., Usmonov F. K., Rakhmanov A. H. Preclinical toxicological study of pasty osteose-substituting material. Сучасні проблеми фармакотерапії І призначення лікарських засобів. March 12-13, 2020 Kharkiv vol. 2, P. 110
Kh. T. Agzamkhodzhayeva, Sh. Ya. Mirzaakhmedov, M. S. Tashmukhamedov. Studies of the acute toxicity of the Bakagin drug on laboratory mice. Ўзбекистон фармацевтик хабарномаси. No. 4, 2018. P. 84-87.
I. A. Bazikov, E. V. Beyer, V. V. Lukinova, A. N. Maltsev. Comparative assessment of the acute toxicity of doxorubicin and its niosomal form. Медицинский вестник Северного Кавказа. 2015. Vol. 10. no. 3. P. 403-406.
V. V. Bagmetova, L. I. Bugaeva, I. N. Tyurenkov, E. A. Kuzubova. Study of citrocard acute toxicity — a new phenibut derivative with cardio- and neuroprotective effects. Вестник ВолгГМУ. Issue 1 (61). 2017. P. 33-35.
A. N. Mironov. Guidelines for conducting preclinical studies of medicines. Part 1. - Moscow. 2012. — 944 p.
A. N. Mironov. Guidelines for conducting preclinical studies of medicinal products (immunobiological medicinal products) Part 2. - Moscow. 2012. — 536 p.
E. S. Yurkevich, I. I. Ilyukova, O. A. Boris, V. A. Grynchak. Determination of acute toxicity (chemical products and their mixtures) in intragastric administration. Minsk. 2015. - 34 p.
Dilshat U. Tulyaganov, Avzal Akbarov, Nigora Ziyadullaeva, Bekhzod Khabilov, and Francesco Baino* Injectable bioactive glass-based pastes for potential use in bone tissue repair. Biomed. Glasses 2020; 6: Р. 23–33
J. Shetty Akhila, Shyamjith, Deepa, M.C.Alwar. Acute toxity studies and determination of median letal dose. Current science. VOL.93, №7. 2007, Р. 917-920.
