THE FREQUENCY OF THE DEVELOPMENT OF MULTIPLE PRIMARY MALIGNANT TUMORS OF THE FEMALE REPRODUCTIVE SYSTEM
Keywords:
metachronous tumors; primary multiple malignant tumors; tumors of the female reproductive system; synchronous tumorsAbstract
The study aimed to investigate the frequency of the development of synchronous and metachronous tumors and the combination of different types of cancer among patients with primary-multiple malignant tumors of the female reproductive system. This is relevant for improving the diagnosis of this category of patients. 80 patients with multiple primary malignant tumors with lesions of the female reproductive system (II-III clinical stages of the disease) were included in the study. This research found that 27.5% of patients had synchronous tumors and 72.5% had metachronous tumors. Among the 38 patients with breast cancer, 23.7% had synchronous cancer of the second breast, and 7.9% had ovarian cancer. Synchronous breast cancer was detected in 22.7% of patients with primary ovarian cancer, 25.0% with uterine body cancer, and 25.0% with cervical cancer. Metachronous tumors were diagnosed in 68.4% of patients with breast cancer, 77.3% with ovarian cancer, 75.0% with uterine body cancer, and 75.0% with cervical cancer. The most common time for metachronous tumors to be detected was between 6 months and 1 year and between 1 year and 2 years in 44.8% of patients. Thus, each female reproductive system tumor should be considered an indicator of other oncopathological risks. And effective dispensary monitoring will allow for monitoring the development of multiple primary malignant tumors in this type of patient in advance.
References
Akulenko L.V. O nasledstvennom rake molochnoj zhelezy, jaichnikov i jendometrija (klinicheskaja lekcija) [On hereditary cancer of the breast, ovary and endometrium (Clinical lecture)] // Problemy reprodukcii [Problems of reproduction], 2004. N6. P.20-27. [in Russian].
Balenkov O.Yu., Yuldasheva D.Yu., Kireev G.V., Kamishov S.V. Study of cancer incidence among the population of Tashkent // Journal of Theoretical and Clinical Medicine No. 3. -2007. -P.90-92. [In Russian]
DE Luca A., Frusone F., Vergine M. et al. Breast cancer and multiple primary malignant tumors: Case report and review of the literature. In vivo // 2019. V.33. P.1313–1324. doi: 10.21873/invivo.11605.
De Luca A., Frusone F., Vergine M. et al. Breast Cancer and Multiple Primary Malignant Tumors: Case Report and Review of the Literature // In Vivo. 2019. V. 33. N4. P.1313-1324. doi:10.21873/invivo.11605
Fedorov V.E., Barsukov V.Yu., Popova T.N. et al. Osobennosti techenija i trudnosti diagnostiki mnozhestvennyh zlokachestvennyh novoobrazovanij [Features of the course and difficulties in the diagnosis of multiple malignant neoplasms] // Medicinskij al'manah [Medical almanac], 2011. N2. P.157-160. [in Russian].
FIGO Committee on Gynecologic Oncology. Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium // Int. J. Gynecol. Obstet. 2009. V.105. N2. P.103-104.
FIGO Committee on Gynecologic Oncology. Revised FIGO staging for carcinoma of the cervix uteri // Int. J. Gynecol. Obstet. 2019. V.145. N1. P.129-135.
International Union Against Cancer (UICC). TNM Classification of Malignant Tumours, 7th ed. Sobin L.H., Gospodarowicz M.K., Wittekind Ch., eds. New York: Wiley-Blackwell; 2009.
Kamishov S.V. Modern immunopharmacotherapy in the complex treatment of cervical cancer // Bulletin of Science and Education. 2018;2 (6), 42
Kamishov S.V., Tillyashaikhov M.N. The Effect of Extracorporeal Immunopharmacotherapy on Intracellular Metabolism in Cervical Cancer Patients // Клиническая и экспериментальная онкология, 2019:11-21.
Kamishov S.V., Pulatov D.A., Yuldasheva N.Sh. Studying the role of molecular biological tumor markers in the choice of immunotherapy method in the accompanying treatment of ovarian and cervical cancer // Eurasian Journal of Oncology. 2015;5(2):53-60. [In Russian]
Kamishov S.V., Yuldasheva N.S., Pulatov D.A. Supportive immunotherapy in complex treatment of patiens with oncogynaecological diseases Bulletin of Science and Education. 2013:158-161 [In Russian]
Kamishov S.V., Yuldasheva N.Sh., Salimova L.R. Study of methods of extracorporeal immunopharmacotherapy as an accompaniment to chemotherapy in patients with ovarian cancer // Oncology and Radiology of Kazakhstan 2010;16 (3-4):96 [In Russian]
Kamishov SV Modern immunopharmacotherapy in the complex treatment of cervical cancer. Bulletin of Science and Education. 2018;2;6(42):57-61. [In Russian].
Kamishov SV, Pulatov DA, Yusupova NB, et al. The state of immunoreactivity of patients with cervical cancer against the background of extracorporeal immunopharmacotherapy. Bulletin of the National. medical surgeon. center them. N.I. Pirogova. 2018;13(1):98-102. [In Russian].
Kaprin A.D., Starinskiy V.V., Petrova G.V. (Ed.) Sostojanie onkologicheskoj pomoshhi naseleniju Rossii v 2016 godu [The state of cancer care for the population of Russia in 2016]. M.: MNIOI im. P.A. Gercena FGBU «NMIRC» Minzdrava Rossii [M.: MNIOI them. P.A. Herzen FSBI "NMIRC" of the Ministry of Health of Russia], 2017. [in Russian].
Maksimov S.Ya. Pervichno mnozhestvennye opuholi organov reproduktivnoj sistemy [Primarily multiple tumors of the organs of the reproductive system] // Prakticheskaja onkologija [Practical Oncology]. 2009. V.10. N2. P.117-123. [in Russian].
Motuzyuk I., Sydorchuk O., Kovtun N. et al. Analysis of trends and factors in breast multiple primary malignant neoplasms // Breast Cancer (Auckl) 2018. V.12:117822341875995. doi: 10.1177/1178223418759959.
Nyqvist J., Parris T..Z, Helou K. et al. Previously diagnosed multiple primary malignancies in patients with breast carcinoma in Western Sweden between 2007 and 2018. Breast. Cancer. Res. Treat. // 2020. V.184. N1. P.221-228. doi:10.1007/s10549-020-05822-z
Ozan H., Ozerkan K., Aker S. et al. A case with three primary tumors of the ovary, endometrium and gallbladder // Eur. J. Gynaecol. Oncol., 2008. V.29. N5. P.551-553.
Sidorenko Yu.S., Shelyakina T.V., Titova E.V. et al. Problemy pervichno-mnozhestvennyh processov u bol'nyh rakom molochnoj zhelezy [Problems of multiple primary processes in patients with breast cancer] // Sibirskij onkologicheskij zhurnal [Siberian Journal of Oncology], 2010. V.37. N1. P.18-22. [in Russian].
Takatori E., Shoji T., Miura Y. et al. Triple simultaneous primary invasive gynecological malignancies: a case report // J. Obstet. Gynaecol. Res., 2014. V.40. N2. P.627-631. doi:10.1111/jog.12199
Tillyashaikhov M.N., Kamishov S.V. Features of the humoral status of immunity in patients with cervical cancer // International scientific review of the problems and prospects of modern science and education. 2018:84-87
Vogt A., Schmid S., Heinimann K. et al. Multiple primary tumours: challenges and approaches, a review // ESMO Open. 2017. V.2. N2. P.e000172–e000172. doi:10.1136/esmoopen-2017- 000172.
Yuldasheva N.Sh., Navruzova V.S., Akhmedov O.M., Umarova N.A. Kamishov S.V. Features of therapeutic tumor pathomorphosis during X-ray endovascular polychemotherapy in the complex treatment of cervical cancer // Oncology and Radiology of Kazakhstan. -2010;16 (3- 4):96-97 [In Russian]
