EVALUATION OF THE EFFECTIVENESS OF THE COMBINATION THERAPY OF HERPETIC STOMATITIS WITH THE ANTIVIRAL DRUG "PROTEFLAZID" AND THE IMMUNOMODULATOR "LIKOPID"
Keywords:
herpetic stomatitis, therapy, proteflazid, licopidAbstract
The article presents the results of the treatment of 20 people suffering from herpes simplex with the help of the immunomodulatory medicine "Likopid" and the antiviral solution "Proteflazid". According to the obtained results, there were revealed an acceleration in the development of the manifestations of this disease and an increase in the period of remission with the help of above-mentioned medicines. The immune system was examined to confirmation of received data.
References
Dolgikh T.N., Minakova E.Yu., Zapariy N.S. Clinical and immunological evaluation of the effectiveness of Kagocel in the treatment of patients with recurrent herpes infection. Russian journal of skin and venereal diseases. 2010. No 1. P. 15-18.
Mezentseva M.V., Narovlyansky A.N., Shcherbenko V.E. Assessment of interferon status and cytokine profile in patients with genital herpes. Russian Journal of Immunology. 2002. No 2. pp. 167-174.
Fli J., Tisminetzky S., Baralle F. Oral transgene vaccination mediated by attenuated Salmonellae is an effective method to prevent Herpes simplex virus-2 induced disease in mice. Vaccine. 2001 Vol. 19. No. 13-14. P. 1772-1782.
Mikloska Z., Rickholdt M., Ghadiminejad I., Dunckle H., Denis M., Cunningham AL. Monophosphoryl lipid A and QS21 increase CDS T-lymphocyte cytotoxicity to herpes simplex virus-2 infected cell proteins 4 and 27 through IFN-gamma and IL-12 production. J Immunol. 2000 Vol. 164. No. 10. P. 5167-5176.
Rabinovich O.F., Rabinovich I.M., Razzhivina N.V. Combined use of Leukinferon with Polyoxidonium in the treatment of recurrent herpetic stomatitis. Clinical dentistry. 2005. No 2. pp. 10.
Mayansky A.N. Pathogenetic microbiology: a guide. N. Novgorod. 2006. 520.
Detection of antigens of the herpes simplex virus at different stages of genital herpes infection using monoclonal antibodies / E.B. Nikitina, P.P. Klimova, V.I. Kulagi, A.A. Kushch // Sexually transmitted infections. - 2000. - No 4. - pp. 17-21.
Dolgikh, T.I. Clinical and immunological evaluation of the effectiveness of Kagocel in the treatment of patients with recurrent herpetic infection / T.I. Dolgikh, E.Yu. Minakova, N.S. Zapariy // Russian Journal of Skin and Venereal Diseases. - 2010. - No 1. - pp. 15-18.
Rabinovich, O.F. Combined use of Leukinferon with Polyoxidonium in the treatment of recurrent herpetic stomatitis / O.F. Rabinovich, I.M. Rabinovich, N.V. Razzhivina // Clinical Dentistry.- 2005.-No2.- SU.
Tutushkina, T.V. A new domestic interferon inducer Kagocel in the treatment of the genital form of chronic recurrent herpes virus infection: Cand. ... cand. medical sciences: 14.00.36 / Tutushkina Tatyana Vladimirovna. - Moscow, 2004. – p.131.
Khaldin, A.A. Immunological substantiation of differentiated approaches to the treatment of herpes simplex: dis. ... doc. medical sciences: 14.00.11 / Aleksey Anatolyevich Khaldin. - Moscow, 2001. - 197p.
