TUG'MA TROMBOFILIYALAR SURUNKALI OBSTRUKTİV O'PKA KASALLIGI BILAN OG’RIGAN BEMORLARDA TROMBOTIK ASORATLAR SABABI SIFATIDA
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chronic obstructive pulmonary disease, thrombophilia, thrombosis, predictors##article.abstract##
O'pkaning surunkali obstruktiv kasalligi bilan og'rigan bemorlarda trombofiliya gen polimorfizmlarining tarqalishini va ularning tromboz rivojlanishi bilan bog'liqligini baholash uchun SOO’K bilan og'rigan 123 bemor tekshirildi, ularni anamnezida tromboz mavjudligiga qarab 2 guruhga bo'lingan ( 1-guruh, anamnezida trombozi bo'lmagan SOO’K bilan og'rigan bemorlar, n=83 va 2-guruh, anamnezida tromboz bo'lgan bemorlar, n=40). Protrombin genining 20210 G/A, Leyden omil genining Arg506Gln, MTR genining Asp919Gly, MTHFR genining Ala222Val, MTHFR genining Glu429Ala va MTRdi genining Ile22Met polimorfizmlari o’rganildi, buning uchun PCR apparatidan foydalanildi.
Tadqiqot natijalari shuni ko'rsatadiki, trombofiliyaning o'rganilgan prediktorlari anamnezida tromboz bo'lgan SOO’K bemorlar guruhlarida sezilarli darajada tez-tez uchraydi. Ushbu qonuniyat to'g'ridan-to'g'ri kuchli trombofiliya genlarining polimorfizmlari uchun ham, bilvosita trombofiliya genlari (gipergomosisteinemiya genlari va endotelin-1 genlari) uchun ham aniqlandi.
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