CONGENITAL THROMBOPHILIA AS A CAUSE OF THROMBOTIC COMPLICATIONS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Keywords:
chronic obstructive pulmonary disease, thrombophilia, thrombosis, predictorsAbstract
In order to assess the prevalence of polymorphisms of thrombophilia predictor genes and their association with the development of thrombosis in patients with chronic obstructive pulmonary disease, 123 patients with COPD were examined, which were divided into 2 groups according to the presence of thrombosis in their anamnesis (Group 1, patients with COPD without thrombosis in history, n=83 and group 2, patients with a history of thrombosis, n=40). Polymorphisms 20210 G/A of the prothrombin gene, Arg506Gln of the Leiden factor gene, Asp919Gly of the MTR gene, Ala222Val of the MTHFR gene, Glu429Ala of the MTHFR gene, and Ile22Met of the MTRR gene were studied.
The results of the study noted that the studied predictors of thrombophilia were significantly more common in groups of patients with a history of thrombosis. This pattern was established both for polymorphisms of direct strong thrombophilia genes and for indirect thrombophilia genes (hyperhomocysteinemia genes and endothelin-1 genes).
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