NEYROSENSOR BUZILISHLAR KUZATILGAN BEMORLARDA IL-10 GENI -819 C/T (rs1800871) POLIMORFIZMINING YURAGI KORONAR KASALLIGINING NOSTABILLANISHIDAGI ROLI
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yurak ishemik kasalligi, interleykin, siydik kislotasi, neyrosensor buzilishlar, beqaror atenokardiya, asimptomatik giperurikemiya##article.abstract##
So'nggi kunlarda koronar arteriya kasalliklari bilan og'rigan bemorlar orasida yurak-qon tomir patologiyalari bo'lgan bemorlarning hayotiga tahdid soladigan asimptomatik va klinik jihatdan aniq giperurikemiya holatlari tez-tez uchrab turadi; shuning uchun yurak-qon tomir kasalliklari bilan og'rigan bemorlarda giperurikemiya kursini o'rganishga qiziqish ortib bormoqda.
Maqsad: IL-10 genining -819 C/T lokusi (rs1800871) polimorfizmi va neyrosensor kasalliklari bo'lgan bemorlarda beqaror stenokardiya rivojlanishi o'rtasidagi munosabatni o'rganish.
Tadqiqot materiallari va usullari: Respublika shoshilinch tibbiy yordam ilmiy markazi Samarqand filiali klinik bazasida 2019 yildan 2021 yilgacha yurak ishemik kasalligi (YUIK) tashxisi qo‘yilgan 97 nafar bemor tekshirildi. Koronar arteriya kasalligi bilan og'rigan bemorlarning o'rtacha yoshi 61,56±12,31 yoshni tashkil etdi.
Tadqiqot natijalari: Barcha bemorlar neyrosensor buzilishlar mavjudligiga qarab 2 guruhga bo'lingan. Tadqiqot davomida 67 bemorda neyrosensor buzilishlar (NSB) aniqlandi. IL-10 genining 819 (rs1800871) C/T polimorfizmining SSG bilan assotsiatsiyasini aniqlash uchun SSG bo'lgan va bo'lmagan NS bemorlari guruhida genning C va T allel chastotalarining taqsimoti o'rganildi, deyarli sog'lom odamlar guruhida IL-10 (C819T) rs1800871 genining C va T allellari turli chastotalarda paydo bo'lganligi aniqlandi.
Xulosa: Shunday qilib, ushbu tadqiqotda keltirilgan zamonaviy laboratoriya diagnostikasi usullari YUIK destabilizatsiyasi rivojlanishining patogenezida biokimyoviy, immunologik va genetik mexanizmlarning ishtiroki muhimligini tasdiqlashga imkon berdi, bu esa o'z navbatida kasallikning rivojlanishiga hissa qo'shadi. Ushbu patologik kasallikni davolash va oldini olishga individual yondashish, shuningdek, prognozni yaxshilash va yurak-qon tomir asoratlari va o'limni kamaytirishga olib keladi.
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