THE ROLE OF IL-10 GENE -819 C/T (rs1800871) POLYMORPHISM IN DESTABILIZATION OF CORONARY HEART DISEASE IN PATIENTS WITH NEUROSENSORY DISORDERS
Keywords:
ischemic heart disease, interleukin, uric acid, neurosensory disorders, unstable angina, asymptomatic hyperuricemiaAbstract
In recent days, among patients with coronary artery disease, there have been frequent cases of asymptomatic and clinically pronounced hyperuricemia, which threaten the lives of patients with cardiovascular pathologies; therefore, interest in studying the course of hyperuricemia in patients with cardiovascular diseases is increasing.
Objective: to study the relationship between the polymorphism of the -819 C/T locus (rs1800871) of the IL-10 gene and the progression of unstable angina in patients with neurosensory disorders.
Materials and methods of research: In the clinical base of the Samarkand branch of the Republican Scientific Center for Emergency Medical Care (SFRSCEMC) from 2019 to 2021. 97 patients diagnosed with coronary heart disease (CHD) were examined. The average age of patients with coronary artery disease was 61.56±12.31 years.
Results of the study: All patients were divided into 2 groups depending on the presence of neurosensory disorders. During the study, neurosensory disorders (NSD) were identified in 67 patients. To determine the association of 819 (rs1800871) C/T polymorphism of the IL-10 gene with HCP, the distributions of the C and T allele frequencies of the gene in the group of АS patients with and without HCP were studied, and in the group of practically healthy individuals it was found that the C and T alleles of the gene IL-10 (C819T) rs1800871 occurred at different frequencies.
Conclusions: Thus, the modern methods of laboratory diagnostics given in this study made it possible to confirm the importance of the participation of biochemical, immunological and genetic mechanisms in the pathogenesis of the development of IHD destabilization, which, in turn, will contribute to the improvement and individual approach to the treatment and prevention of this pathological disease. conditions, as well as improve prognosis and reduce cardiovascular complications and mortality.
References
Ткаченко Г.А., Маливанова Т.Ф. (2017). Зависимость ситуационной тревоги и депрессии от полиморфизма - 238 (G/A) TNF у операбельных больных раком молочной железы// Психологические исследования. Т.10, №51. С.4. URL: http:// psystudy.ru (дата обращения: 21.08.2017).
Ташкенбаева Э. Н. и др. DESTABILIZATION OF ISCHEMIC HEART DISEASE IN PATIENTS WITH ANXIETY-DEPRESSIVE SYNDROME //Вестник экстренной медицины. – 2021. – Т. 14. – №. 1. – С. 11-18.
Насырова З., Абдуллоева М., Усаров Ш. СТРАТИФИКАЦИЯ ФАКТОРОВ РИСКА ПРИ ИШЕМИЧЕСКОЙ БОЛЕЗНИ СЕРДЦА //Журнал кардиореспираторных исследований. – 2021. – Т. 2. – №. 3. – С. 14-17.
Ташкенбаева Э. и др. ХРОНИЧЕСКАЯ СЕРДЕЧНАЯ НЕДОСТАТОЧНОСТЬ КАК ВЕДУЩАЯ МЕДИКО-СОЦИАЛЬНАЯ И ЭКОНОМИЧЕСКАЯ ПРОБЛЕМА //Журнал кардиореспираторных исследований. – 2021. – Т. 2. – №. 3. – С. 18-21.
Элламонов С. Н. и др. ФАКТОРЫ ПРОГРЕССИРОВАНИЯ АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИИ У БОЛЬНЫХ В КОМОРБИДНОСТИ С САХАРНЫМ ДИАБЕТОМ 2 ТИПА //Журнал кардиореспираторных исследований. – 2021. – Т. 2. – №. 2.
De Bacquer D., De Smedt D., Kotseva K., et al.(2019). Incidence of cardiovascular events in patients with stabilized coronary heart disease: the EUROASPIRE IV follow-up study. Eur J Epidemiol. 34(3), 247-258. doi:10.1007/s10654-018-0454-0
De Hert M., Detraux J., Vancampfort D.(2018). The intriguing relationship between coronary heart disease and mental disorders. Dialogues Clin Neurosci.20(1),31-40.
Han W, Zhang H, Gong X, et al.(2019). Association of SGK1 Polymorphisms With Susceptibility to Coronary Heart Disease in Chinese Han Patients With Comorbid Depression. Front Genet.10, 921. Published 2019 Oct 1. doi:10.3389/fgene.2019.00921
Haybar H, Shirani T, Pakseresht S.(2018) Evaluation of cardiac rehabilitation on functional capacity in depressed and nondepressed patients after angioplasty. J Family Med Prim Care.;7(6),1304-1308. doi:10.4103/jfmpc.jfmpc_306_18
Haapakoski R., Mathieu J., Ebmeier K.P., Alenius H., Kivimäki M. (2015). Cumulative meta-analysis of interleukins 6 and 1β, tumour necrosis factor α and C-reactive protein in patients with major depressive disorder. Brain Behav. Immun. 49, 206–215. doi: 10.1016/j.bbi.2015.06.001
Moreira D.M., da Silva R.L., Vieira J.L., Fattah T., Lueneberg ME, Gottschall C.A. (2015). Role of vascular inflammation in coronary artery disease: potential of anti-inflammatory drugs in the prevention of atherothrombosis. Inflammation and anti- inflammatory drugs in coronary artery disease. Am J Cardiovasc Drugs; 15, (1)I-II.
Tashkenbaeva Eleonora and all.(2020). The Role of Biopsychosocial Risk Factors on the Intensification of Unstable Angina// Internatsional Journal of Advanced Science and Technology. 29(5), 1948-1952.
Tashkenbaeva E.N., Rajabova N.T., Nasyrova Z.A., Kadirova F. Sh.(2020). Impact of lipid metabolism disorders and psychological risk factors on the development of cardiovascular disease among women of different age categories//Journal of Critical Reviews 7, (12), 991-993.
Tashkenbaeva E.N., Rajabova N.T., Nasyrova Z.A., Kadirova F. Sh. (2020). The impact of the cytokine imbalance on angina destabilization in women of different age categories// Academicia an international multidisciplinary research journal, 10 (6), 732-738. DOI 10.5958/2249-7137.2020.00642.4
Van Montfort, F.A. Meyer, R. von Känel, H. Saner, J.P. Schmid, S. Stauber (2015). Positive affect moderates the effect of negative affect on cardiovascular disease-related hospitalizations and all-cause mortality after cardiac rehabilitation Eur J Prev Cardiol, 22, 1247-1253.
Vieira É.L., de Oliveira G.N., Lessa J.M., Gonçalves A.P., Sander J.W., Cendes F., Teixeira A.L. (2015). Interleukin-1β plasma levels are associated with depression in temporal lobe epilepsy. Epilepsy Behav.53,131– 134. doi: 10.1016/j.yebeh.2015.09.035
Xu HM, Liu YR (2015). Role of interleukin-10 gene polymorphisms in the development of coronary artery disease in Chinese population. Genet Mol Res. 14(4), 15869-15875. Published 2015 Dec 3. doi:10.4238/2015.December.1.38
Zhou Y, Zhao M, Pu Z, Xu G, Li X.(2018). Relationship between oxidative stress and inflammation in hyperuricemia: Analysis based on asymptomatic young patients with primary hyperuricemia. Medicine (Baltimore). 97(49), 13108. doi:10.1097/MD.0000000000013108
