KEKSA YOSHDAGI BEMORLARDAGI ASORATLANGAN PNEVMONIYADA SITOKINLAR SPEKTRINING PROGNOSTIK QIYMATINI O'ZGARISHI
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virusli infeksiya, pnevmoniya, sitokin spektri, interleykinlar##article.abstract##
Virusli infeksiyadagi immunitet holatining o'ziga xos xususiyati IgA ning uzoq muddatli selektiv yetishmovchiligida, shu jumladan yuqori IgE darajasi, fagotsitoz ko'rsatkichlarining pasayishi va kontsentratsiyaning oshishi bilan namoyon bo'ladi. Virusli infeksiya B-limfotsitlar darajasining oshishi va IgA, IgG va IgE, shuningdek IL-4 ning haddan tashqari ko'payishi bilan tavsiflanadi. Tadqiqotlar ifn-γ va IL-1b kontsentratsiyasi o'rtasidagi bog'liqlik mavjudligini tasdiqlaydi va bu bog'liqlik to'g'ridan-to'g'ri va virusli pnevmoniya kursining og'irligiga qarab kamayadi, bu immunoregulyatsiya mexanizmlarining buzilishini ko'rsatadi. Sitokinlar darajasi – IL 1b, TNF-a va il-4 og'ir murakkab pnevmoniya bilan og'rigan bemorlarda keskin ko'tariladi. Olingan natijalar metabolik jarayonlarning buzilishini va ushbu kasallikning asoratlarini rivojlanishiga hissa qo'shadigan aniq immunologik o'zgarishlarni ko'rsatadi. Ko'pincha o'tkir nafas etishmovchiligi (OʻNYe), tarqalgan tomir ichi pıhtılaşma sindromi (DVSK), yuqumli toksik shok (ITSH), plevrit va xo'ppoz rivojlanishi sodir bo'ldi. Bir qator bemorlarda o'pka to'qimalarining shikastlanishi va bu fonda asoratlar reanimatsiya bo'limida intensiv terapiyaga qaramay tez rivojlandi.
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