BOSH MIYA PARENXIMA STRUKTURALARIDAGI PATOLOGIK JARAYONLARNI DIAGNOSTIKA QILISHDAGI INTEGRATIV MRTNING ROLI
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magnit-rezonans tomografiya, neyrovizualizatsiya, diffuzion tensor tasvirlash, MR- spektroskopiya, perfuziya vazog'irligi, kvantitativ neyroradiologiya##article.abstract##
Maqsad: Magnit-rezonans tomografiyaning (MRT) zamonaviy protokollari asosida bosh miya parenximasidagi patologik jarayonlarni differensial diagnostika qilishda kvantitativ parametrlarning prognostik ahamiyatini aniglash. Material va metodlar: 2021-2025 yillar davomida 107 nafar bemorda prospektiv kohort tadqiqot o'tkazildi. Barcha sub'ektlar standart MRT protokoli (T1-WI, T2- WI, FLAIR, DWI, SWI) asosida tekshirildi. 92% hollarda gadoliniy asosidagi kontrast moddalar qo'llanildi. 23 bemorda MR-spektroskopiya, 19 bemorda MR-perfuziya va 13 bemorda diffuzion tensor tasvirlash (DTI) qo'llanildi. Kvantitativ tahli l uchun ADC (Apparent Diffusion Coefficient) qiymatlari, rCBV (relative Cerebral Blood Volume) va metabolit nisbatlari hisoblandi. Natijalar: MRT ning umumiy diagnostik anikligi 97.3% ni tashkil etdi. ADC qiymatlarining analizi metastatik lezyonlarni (0.72 ± 0.08 ×10⁻³ mm²/s) glioblastoma multiformedan (0.83 ± 0.11 ×10⁻³ mm²/s) ajratishda 94.2% sezgirlikka erishdi (p<0.001). rCBV qiymatlari meningiomalarda (8.3 ± 2.1) gliomalarga (5.2 ± 1.8) qaraganda sezilarli darajada yuqori bo'ldi (p<0.01). MR-spektroskopiyada Cho/NAA nisbatining 2.5 dan yuqori bo'lishi malign progressiyaning prognostik ko'rsatkichi sifatida 45.7% aniklikni namoyish etdi. Xulosa: MRT ning multiparametrik yondashuvi bosh miya parenximasidagi patologik jarayonlarni differensial diagnostika qilishda reproduktiv va kvantitativ metodologiyani taklif etadi. Kvantitativ MR parametrlar morfofunksional korrelyatsiyani o'rnatish va individual prognostik modellarni ishlab chiqish imkoniyatini beradi.
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