CLINICAL LABORATORY CHANGES IN DIABETIC NEPHROPATHY
Keywords:
diabetic nephropathy, laboratory analysis, type 2 diabetes mellitusAbstract
Objective: Assessment of the severity of the disease complicated by diabetic nephropathy based on laboratory parameters.
Methods: The study was carried out on the basis of the Samarkand Regional General Hospital, Department of Nephrology. To achieve this goal, a retrospective study of patients' medical records was conducted. The number of patients with nephropathy in diabetes mellitus is 20. Of these, 12 (60%) are men, 8 (40%) are women. The average of the patients was 59.5 years.
The results obtained: The main group included 20 patients with various courses of nephropathy. During clinical and laboratory examination, it turned out that in the general analysis of blood, the main changes are associated with red blood cells, which is manifested by a decrease in their number. The erythrocyte sedimentation rate (ESR) in all patients is sharply increased. When studying the biochemical parameters of the serum of patients, it was found that the residual nitrogen products are sharply increased, in all patients the level of cholesterol is moderately increased and the total protein is lowered.
A general analysis of urine revealed protein in high concentrations, leukocytes and erythrocytes in insignificant amounts.
Conclusions. In a significant part of the analyzed patients, changes in laboratory tests indicate that nephropathy is at the terminal stage of chronic renal failure.
References
Berdiyarova ShSh, Yusupova NA, Murtazaeva NK, Halimova S. Modern aspects of laboratory diagnosis of chronic osteomyelitis in children. International scientific research journal. 2022; 2(10): 11-1
Coffey, J.T., Brandle, M., Zhou, H. et al, Valuing health-related quality of life in diabetes. Diabetes Care. 2017; 2238–2243.
Dushanova GA, Nabieva FS, Sadinova MZh, Nurmatova D.M. Analysis of the relationship between the parameters of immune homeostasis and the state of the LPO-AOS system. Bulletin of Science and Education.2021; 2(105):63-69
Garber AJ, Abrahamson MJ, Barzilay JI. AACE Comprehensive Diabetes Management Algorithm. J. Endocr. Pract. 2013; 2: 327-336.
Ibragimova, N.S. Ibragimova. The role of homocysteine in the pathogenesis of polycystic ovary syndrome in women B.F.International scientific review. 2020; 3: 3
Jichlinski P..Urology. Rev Med Suisse. 2014; 10 (412-413): 127-9.
Spiridonova ES. Medical and social characteristics of patients with urological pathology. Nursing and higher nursing education: materials of a practical conference.2010; 3: 60-62.
Pomerantsev VP. Diagnosis, treatment and quality of life. Clinical medicine. 2018; 9: 3.
Ospanova ТС, Zaozerskaya IV. Changes in the quality of life of patients at different stages of chronic kidney disease in diabetes mellitus. Scientific bulletins. Series Medicine. Pharmacy. 2013; 25 (168): 60- 65.
