OPTIMIZING THE TREATMENT OF CHRONIC POLYPOSIS RHINOSINUSITIS
Keywords:
Polypous rhinosinusitis (PRS), symptomatic treatment , surgical treatmentAbstract
Polypous rhinosinusitis (PRS) is a chronic inflammatory disease of the mucous membrane of the nasal cavity and paranasal sinuses, characterized by the formation and recurrent growth of polyps, consisting predominantly of edematous tissue infiltrated with eosinophils. Undoubtedly, PRS represents a very serious and unresolved problem in modern medicine. Patients with PRS make up 5% of those visiting ENT clinics and 4% of those visiting an allergist.
Complex treatment was used in 161 patients with chronic polypous rhinosinusitis.
In the first group (29 patients) surgery was combined with a symptomatic treatment, in the second group (92 patients) surgical treatment was combined with peroral intake of antihistaminic drugs and application of hyoxyson ointment to the nasal mucosa.
Patients of the third group (40 persons) were treated in a way similar to that of the second one, but intravenous injections of sodium thiosulfate was also used in them.
Immediate and long-term results appeared to be better in patients of the 3d group.
References
Ahmadiafshar A, Farjd HR, Moezzi F, Mousavinasab N. Nasal polyposis in patients with asthma and allergic rhinitis. J Laryngol Otol. 2012;126(8):780-783. doi:10.1017/S0022215112000771
Bachert C, Gevaert P, Holtappels G, Johansson SG, van Cauwenberge P. Total and specific IgE in nasal polyps is related to local eosinophilic inflammation. J Allergy Clin Immunol. 2001;107(4):607-614. doi:10.1067/mai.2001.112374.
Bachert C, Zhang N, Holtappels G, De Lobel L, van Cauwen- berge P, Liu S, Lin P, Bousquet J, Van Steen K. Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma. J Allergy Clin Immu¬ nol. 2010;126(5):962-968. doi: 10.1016/j.jaci.2010.07.007.
Bhattacharyya N., Kepnes L. J. Medications prescribed at ambulatory visits for nasal polyposis. Am J Rhinol Allergy. 2013;27:479-481. DOI: 10.2500/ajra.2013.27.3969
Bolger WE, Butzin CA, Parsons DS. Paranasal sinus bony anatomic variations and mucosal abnormalities: CT analysis for endoscopic sinus surgery. Laryngoscope. 1991;101:56-64. doi:10.1288/00005537-199101000-00010..
Budkovaya M. A. Kompleksnaya otsenka immunologicheskikh i fiziologicheskikh aspektov pri lechenii polipoznogo rinosinusita [Complex evaluation of immunological and physiological aspects in the treatment of polypous rhinosinusitis. Rossiiskaya otorinolaringologiya. 2015. (S1): 34–41 (in Russ) .
Bunnag C, Pacharee P, Vipulakom P, Siriyananda C. A study of allergic factor in nasal polyp patients. Ann Allergy. 1983;50(2):126- 132.
Chen Y. T. [et al.]. Asthma associated with chronic rhinosinusitis: a population-based study. International Forum of Allergy and Rhinology. 2016;12(6):1284–1293. doi: https://doi.org/10.1002/alr.21813
Dabirmoghaddam P., Mehdizadeh Seraj J., Bastaninejad S., Meighani A., Mokhtari Z. The efficacy of clarithromycin in patients with severe nasal polyposis. ActaMed Iran. 2013;51:359-364. http://acta.tums.ac.ir/index.php/acta/ article/view/4430
Demarco R.C, Tamashiro E, Rossato M, Ferreira MD, Valera FC, Anselmo-Lima WT. Ciliary ultrastructure in patients with chronic rhinosinusitis and primary ciliary dyskinesia. Eur Arch Oto Rhino Laryngol. 2013;270(7):2065-2070. doi: 10.1007/s00405-012-2342-7/.
Epidemiologiya polipoznix rinosinusitov Lancov A.A. Ryazancev S.V. СПб., 1999. 96 с. (in Russ)
Klinicheskie rekomendacii Nacionalnogo soglasitelnogo komiteta “Polipozniy rinosinusit”. М. 2010. (in Russ)
Nasretdinova M. T., Makhmudova N. R., Khaitov A. A. IMPROVEMENT OF DIAGNOSTICS IN CHILDREN WITH CHRONIC PURULENT RHINOSINUSITIS //The 5th International scientific and practical conference “Modern scientific research: achievements, innovations and development prospects” (October 24-26, 2021) MDPC Publishing, Berlin, Germany. 2021. 686 p. – 2021. – P. 122. (in Russ.)
Taxsinovna N. M. et al. YUQORI JAG’BUSHLIG’I KISTOZLI ZARARLANISHIDA JARROHLIK YONDASHUVINI TAKOMILLASHTIRISH //JOURNAL OF BIOMEDICINE AND PRACTICE. – 2024. – Т. 9. – №. 2. (in Russ.)
Taxsinovna NM et al. CHRONIC POLYPOSIS RHINOSINUSITIS //JOURNAL OF BIOMEDICINE AND PRACTICE. – 2023. – Vol. 8. – No. 6. (in Russ.)
Varvyanskaya A. V., Lopatin A. S. The effectiveness of long-term treatment of polypous rhinosinusitis with low doses of macrolides. Vestnik otorinolaringologii. 2013;78(5): 22–27. doi: 10.1002/alr.21318. (in Russ)
Polipoznyi rinosinusit. Klinicheskie rekomendatsii. Natsional’naya assotsiatsiya otorinolaringologov, 2016. 21 p. (in Russ.). https://legalacts.ru/doc/klinicheskie-rekomendatsii-polipoznyi-rinosinusit-utv-minzdravom-rossii/.
Savlevich E. L., Kozlov V. S., Kurbacheva O. M. Modern trends in the diagnostic and treatment of chronic rhinosinusitis with nasal polyps. Rossiiskaya rinologiya. 2018;26(2):41–47. (in Russ.) https://doi. org/10.17116/rosrino201826241 .
Savlevich E. L., Khaidukov S. V., Kurbacheva O. М., Bondareva G. P., Shachnev K. N., Simbirtsev A. S. Characteristics of cellular immune status in the patients with chronic rhinosinusitis with nasal polyps. Medical Immunology. 2017;19(6):731–738 (in Russ.). doi: 10.15789/1563-0625-2017-6-731-738 .