O‘ZBEK AHOLISIDA PREEKLAMPSIYA RIVOJLANISHIDA TOMIR TONUSI VA ENDOTELIY DISFUNKSIYASI POLIMORFIZMINING GENLARI
##article.subject##:
preeklampsiya, qon tomir tonus genlari, endotelial disfunksiya genlari##article.abstract##
Preeklampsiya homiladorlikning jiddiy asoratlaridan biri bo'lib, ona va homilaning sog'lig'iga ta'sir qiladi. Tadqiqotning maqsadi qon tomir tonusini va endotelial disfunktsiyani tartibga solish uchun javobgar bo'lgan eng ko'p o'rganilgan gen polimorfizmlarining rolini o'rganish edi. Tadqiqot natijalari NOS3 gen tuzilishida PE rivojlanishida xavf (G alleli/GG genotipi) va himoya (T alleli) belgilari mavjudligini ko'rsatdi. Aldosteron sintaza genining rs1799998 polimorfizmining mutant allel T ni tashish ham preeclampsiya rivojlanish xavfi bilan bog'liq. Ushbu lokuslarning haplotip tahlili preeclampsiya rivojlanishida xavfli TG (P = 0,02, OR = 1,7) va himoya KT (P = 0,015, OR = 0,21) haplotiplarining mavjudligini aniqladi.
Библиографические ссылки
Барановская Е.И. Гипертензия у беременных и преэклампсия //Медицинские новости. – 2017. -№6 (273)- С.4-7.
Duley, L. The global impact of pre-eclampsia and eclampsia. Semin. Perinatol. 33, 130–137 (2009)
Jim B., Karumanchi S.A. Preeclampsia: Pathogenesis, Prevention, and Long-Term Complications. Semin Nephrol. 2017; 37(4):386-97.
Knight M., Nair M., Tuflhell D., Kenyon S., Judy S., Brocklehurst P., et al. Saving Lives, Improving Mothers’ Care: Surveillance of maternal deaths in the UK 2012-14 and lessons learned to inform maternity care from the UK and Ireland Confidential Enquiries into Maternal Deaths and Morbidity 2009-14 [Internet]. Oxford: National Perinatal Epidemiology Unit. 2016. 1-102 p.
Lisonkova S., Joseph K.S. Incidence of preeclampsia: risk factors and outcomes associated with early- versus late-onset disease. Am J Obstet Gynecol. 2013; 209(6):544.el-544.el2.
Lo J.O., Mission J.F., Caughey A.B. Hypertensive disease of pregnancy and maternal mortality. Curr Opin Obstet Gynecol. 2013; 25(2): 124-32.
Mostello D., Kallogjeri D., Tungsiripat R., Leet T. Recurrence of preeclampsia: effects of gestational age at delivery of the first pregnancy, body mass index, paternity, and interval between births. Am J Obstet Gynecol. 2008;199(1):55.e1-7. https://doi.org/10.1016/j.ajog.2007.11.058.
Oostwaard M.F., Langenveld J., Schuit E. et al. Recurrence of hypertensive disorders of pregnancy: an individual patient data metaanalysis. Am J Obstet Gynecol. 2015;212(5):624.e1-17. https://doi.org/10.1016/j.ajog.2015.01.009.
Redman, C. W. G. & Staff, A. C. Preeclampsia, biomarkers, syncytiotrophoblast stress, and placental capacity. Am. J. Obstet. Gynecol. 213, e1–S9 e4. (2015).
Say, L. et al. Global causes of maternal death: a WHO systematic analysis. Lancet Glob. Health 2, e323–e333 (2014).
Valgerdur Steinthorsdottir et al. Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women NATURE COMMUNICATIONS (2020) 11:5976
