GENES OF POLYMORPHISM OF VASCULAR TONE AND ENDOTHELIAL DYSFUNCIA IN THE DEVELOPMENT OF PRE-ECLAMPSIA IN THE UZBEK POPULATION
Keywords:
preeclampsia, vascular tone genes, endothelial dysfunction genesAbstract
Preeclampsia is a serious complication of pregnancy that affects the health of both mother and fetus. The aim of the study was to study the role of the most studied gene polymorphisms responsible for the regulation of vascular tone and endothelial dysfunction with the risk of preeclampsia. The results of the study showed the presence in the NOS3 gene structure of risk (G allele/GG genotype) and protective (T allele) markers in the development of PE. The carriage of the mutant allele T of the rs1799998 polymorphism of the aldosterone synthase gene is also associated with the risk of developing PE. Haplotype analysis of these loci revealed the presence of risky TG (P=0.02, OR=1.7) and protective CT (P=0.015, OR=0.21) haplotypes in the development of PE.
References
Барановская Е.И. Гипертензия у беременных и преэклампсия //Медицинские новости. – 2017. -№6 (273)- С.4-7.
Duley, L. The global impact of pre-eclampsia and eclampsia. Semin. Perinatol. 33, 130–137 (2009)
Jim B., Karumanchi S.A. Preeclampsia: Pathogenesis, Prevention, and Long-Term Complications. Semin Nephrol. 2017; 37(4):386-97.
Knight M., Nair M., Tuflhell D., Kenyon S., Judy S., Brocklehurst P., et al. Saving Lives, Improving Mothers’ Care: Surveillance of maternal deaths in the UK 2012-14 and lessons learned to inform maternity care from the UK and Ireland Confidential Enquiries into Maternal Deaths and Morbidity 2009-14 [Internet]. Oxford: National Perinatal Epidemiology Unit. 2016. 1-102 p.
Lisonkova S., Joseph K.S. Incidence of preeclampsia: risk factors and outcomes associated with early- versus late-onset disease. Am J Obstet Gynecol. 2013; 209(6):544.el-544.el2.
Lo J.O., Mission J.F., Caughey A.B. Hypertensive disease of pregnancy and maternal mortality. Curr Opin Obstet Gynecol. 2013; 25(2): 124-32.
Mostello D., Kallogjeri D., Tungsiripat R., Leet T. Recurrence of preeclampsia: effects of gestational age at delivery of the first pregnancy, body mass index, paternity, and interval between births. Am J Obstet Gynecol. 2008;199(1):55.e1-7. https://doi.org/10.1016/j.ajog.2007.11.058.
Oostwaard M.F., Langenveld J., Schuit E. et al. Recurrence of hypertensive disorders of pregnancy: an individual patient data metaanalysis. Am J Obstet Gynecol. 2015;212(5):624.e1-17. https://doi.org/10.1016/j.ajog.2015.01.009.
Redman, C. W. G. & Staff, A. C. Preeclampsia, biomarkers, syncytiotrophoblast stress, and placental capacity. Am. J. Obstet. Gynecol. 213, e1–S9 e4. (2015).
Say, L. et al. Global causes of maternal death: a WHO systematic analysis. Lancet Glob. Health 2, e323–e333 (2014).
Valgerdur Steinthorsdottir et al. Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women NATURE COMMUNICATIONS (2020) 11:5976
