BACHADON LEYOMIOMASINING IMMUNO-BIOXIMIYOVIY VA GISTOLOGIK XUSUSIYATLARINING BATAFSIL TAHLILI
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bachadon leyomiomasi, spontan tushish, ektopik homiladorlik, giperpoli menoreya, chanoq sohasida og‘riq, algomenoreya, hayzning nomutanosibligi, dispareuniya, sitokinlar##article.abstract##
Bachadon leyomiomasi turli yoshdagi ayollar o‘rtasida, ayniqsa, reproduktiv yoshdagi ayollarda keng tarqalgan ginekologik kasallik hisoblanadi. Ushbu kasallikning klinik xususiyatlari va patofiziologik mexanizmlarini o‘rganish maqsadida bachadon leyomiomasi tashxisi qo‘yilgan 20 yoshdan 49 yoshgacha bo‘lgan 120 ayol ishtirokida kompleks klinik tadqiqot o‘tkazildi. Bemorlarning ko‘pchiligi 40-49 yoshdagi ayollar (90 nafar) bo‘lib, ularning aksariyat qismi o‘zbek millatidan (106 ayol, 88,3%) edi. Tekshirishlar natijasiga ko‘ra, mazkur patologiya ayollar o‘rtasida o‘rta maxsus ma'lumotga ega bo‘lganlar (71,6%) va uy bekalari (51,6%) orasida ko‘proq tarqalgan. Tadqiqotda ishtirok etgan ayollarning to‘liqlik joylashuvi anamnezi ham o‘rganildi, ularning 14,2% spontan tushish holatlarini, 17,5% rivojlanmagan homiladorlikni va 2,5% ektopik homiladorlik tarixiga ega ekanligini ma'lum bo‘ldi. Bemorlar orasidagi asosiy shikoyatlar giperpolimenoreya (51,6%), chanoq sohasidagi og‘riqlar va algomenoreya (36,7%), hayzning nomutanosibligi (59,2%), dispareuniya (27,5%) va bepushtlik (22,5%) kabi holatlarni o‘z ichiga olgdi. Ma'lumotlarning statistik tahlili parametrik va noparametrik usullardan foydalanib o‘tkazildi, bu klinik va laboratoriya topilmalarida sezilarli o‘zgarishlarni aniqladi. Masalan, bachadon leyomiomasi bilan og‘rigan bemorlarda yuqori darajadagi IL-6 va TNF-α kabi provospalator sitokinlar va TGF-β2 va VEGF kabi o‘sish omillari yuqori darajada ekanligi aniqlandi, bu esa faol yallig‘lanish va proliferativ jarayonlarning mavjudligini ko‘rsatadi.
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