IMMUNO-BIOCHEMICAL AND HISTOLOGICAL CHARACTERISTICS OF UTERINE LEIOMYOMA
Keywords:
uterine leiomyoma, spontaneous miscarriages, ectopic pregnancies, hyperpolymenorrhea, pelvic pain, algomenorrhea, menstrual irregularities, dyspareunia, cytokinesAbstract
Uterine leiomyoma is a common gynecological condition that affects women of various age groups, particularly those in their reproductive years. To explore the clinical characteristics and underlying pathophysiological mechanisms of this condition, a comprehensive clinical study was conducted involving 120 women diagnosed with uterine leiomyoma, aged 20 to 49 years. The majority of the participants were women aged 40 to 49 years (90 individuals), with a significant predominance of Uzbek nationality (106 women, 88.3%). Educational and occupational analyses revealed a higher prevalence of this pathology among women with secondary specialized education (71.6%) and housewives (51.6%). The study also highlighted the complex obstetric history of the participants, with 14.2% reporting spontaneous miscarriages, 17.5% experiencing non-developing pregnancies, and 2.5% having a history of ectopic pregnancies. The primary complaints among the patients included hyperpolymenorrhea (51.6%), pelvic pain and algomenorrhea (36.7%), menstrual irregularities (59.2%), dyspareunia (27.5%), and infertility (22.5%). Statistical analysis of the data involved both parametric and non-parametric methods, revealing significant clinical and laboratory findings. For instance, patients with uterine leiomyoma exhibited elevated levels of pro-inflammatory cytokines, such as IL-6 and TNF-α, and growth factors like TGF-β2 and VEGF, which are indicative of active inflammatory and proliferative processes.
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