QIN VA BACHADON APLAZIYASI BILAN OG‘RIGAN BEMORLARDA TUXUMDONLAR GENEZISINING GIPERANDROGENIYASI BILAN BIRGALIKDA DAVOLANISH DINAMIKASIDAGI GORMONAL, BIOKIMYOVIY VA SONOGRAFIK BUZILISHLARNING XUSUSIYATLARI
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Rokitanskiy-Mayer-Kyuster-Xauzer sindromi, sigmoidal kolpopoez, tuxumdon genezli giperandrogenizmi##article.abstract##
Qin va bachadon aplaziyasi (Mayer-Rokitanskiy-Küster-Hauzer sindromi, MMRKH) karyotipi 46, XX bo'lgan ayollarda bachadon va qinning yuqori uchdan ikki qismining yo'qligi bilan tavsiflangan tug'ma anomaliyadir. Tuxumdon kelib chiqishi giperandrogenizmi bilan birgalikda bu holat murakkab gormonal, biokimyoviy va sonografik kasalliklar bilan birga keladi, bu davolanishga individual yondashuvni talab qiladi. Maqsad: Davolanish jarayonida tuxumdon kelib chiqishi giperandrogenizmi bilan birgalikda qin va bachadon aplaziyasi bo'lgan bemorlarda gormonal, biokimyoviy va sonografik o'zgarishlar dinamikasini baholash. 66 nafar ayol tekshirildi, ulardan 36 nafarida qin va bachadon aplaziyasi hamda giperandrogenizm, 30 nafarida giperandrogenizm kuzatildi. Davolash turmush tarzini o'zgartirish, farmakoterapiya va jarrohlik tuzatishni o'z ichiga oladi. Tekshiruvlarga gormonal tahlil, biokimyoviy testlar, ultratovush va MRI kiradi. Davolash gormonal darajalarni normallashtirishga, testosteron va prolaktin darajasining pasayishiga va biokimyoviy ko'rsatkichlarni, shu jumladan lipid profilini yaxshilashga yordam berdi. Asosiy guruhdagi bemorlar metabolik parametrlarda sezilarli yaxshilanishni ko'rsatdilar. Xulosa: SMRCC va giperandrogenizm bilan og'rigan bemorlarni davolashga individual yondashuv gormonal, biokimyoviy va sonografik holatni yaxshilashga imkon beradi.
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