FEATURES OF HORMONAL, BIOCHEMICAL, AND SONOGRAPHIC DISORDERS IN PATIENTS WITH VAGINAL AND UTERINE APLASIA COMBINED WITH OVARIAN HYPERANDROGENISM DURING TREATMENT DYNAMICS
Keywords:
Mayer-Rokitansky-Küster-Hauser syndrome, sigmoid colpopoiesis, ovarian hyperandrogenismAbstract
Vaginal and uterine aplasia (Mayer-Rokitansky-Küster-Hauser syndrome, MRKH) is a congenital anomaly characterized by the absence of the uterus and the upper two-thirds of the vagina in women with a 46, XX karyotype. When combined with ovarian hyperandrogenism, this condition is accompanied by complex hormonal, biochemical, and sonographic disorders that require an individualized approach to treatment. Objective: To evaluate the dynamics of hormonal, biochemical, and sonographic changes in patients with vaginal and uterine aplasia combined with ovarian hyperandrogenism during treatment. A total of 66 women were examined, 36 with vaginal and uterine aplasia and hyperandrogenism, and 30 without hyperandrogenism. The treatment included lifestyle modification, pharmacotherapy, and surgical correction. The studies involved hormonal analysis, biochemical tests, ultrasound, and MRI. The treatment contributed to the normalization of the hormonal profile, reduction in testosterone and prolactin levels, and improvement of biochemical parameters, including lipid profile. Significant improvement in metabolic parameters was observed in the main group of patients. Conclusion: An individualized approach to the treatment of patients with MRKH and hyperandrogenism allows for the improvement of hormonal, biochemical, and sonographic status, confirming the necessity of a comprehensive and personalized approach in the management of this pathology.
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