PLASENTAL O'SISH FAKTORI VA ERIRILGAN FMS-TYROSINKINASE-1 NISBATINING PREKLAMPSIYADA DIAGNOSTIK AHIMIYATI
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Preeklampsiya, homiladorlik, genetika, platsenta o'sish faktori, eruvchan fms ga o'xshash tirozin kinaz-1, gipertoniya##article.abstract##
Preeklampsiya - bu onalik kasalligi va o'limining yuqori ko'rsatkichlarini belgilaydigan akusherlikdagi eng og'ir asoratlardan biridir. Patologiya homila uchun xavfli holat bo'lib qolmoqda, bu esa homilaning o'sishni sustlashishiga, muddatidan oldin tug'ilishga, homila past vazniga va perinatal o'limga olib keladi. Homiladorlikning ushbu asoratining paydo bo'lishi uchun ko'plab gipotezalar mavjud, ular orasida eng dolzarb nazariya shundaki, u preeklampsiyani multifaktorial kasallik deb hisoblaydi, uning rivojlanishida ko'plab genetik va atrof-muhit omillari ishtirok etadi.
Библиографические ссылки
Преэклампсия. Руководство. Библиотека врача-специалиста. Под ред. Сухих Г.Т., Мурашко Л.Е. М.: ГЭОТАР-Медиа. 2010;576.
Carty DM, Delles C, Dominiczak AF. Preeclampsia and future maternal health. J Hypertens 2010; 28: 1349–1355.
Foidart YM, Schaaps YP, Chantraine F. et al. Dysregylation of anti-angiogenic agents (sFlt-1, PlGF and sendoglin) in preeclampsia — a step forward but not the definitive answer. J Reprod Immunol. 2009;82:106-111.
Hammerova L, Chabada J, Drobny J, Batorova A. Lonfi tudinal evaluation of markers of hemostasis in pregnancy. Bratisl Lek Listy 2014; 115 (3): 140–144.
McElrath T, Lim K-H, Pare E, Rich-Edwards J. et al. Longitudinal evaluation of predictive value for preeclampsia of circulating angiogenic factors through pregnancy. Am J Obst Ginecol. 2010; 11;407:e1-e7.
Verlohren S, Herraiz Y, Lapaire O. et al. The sFlt-1/PlGF radio in different types of hypertensive pregnancy disorders and its prognostic potential in peeclamptic patients. Am J of Obstet Gynecol. 2012;1:58:e1-e8.
Lam C, Lim K-H, Karumanchi SA. Circulating angiogenic factors in the pathogenesis and prediction of preeclampsia. Hypertension Res. 2005;46:1077-1085.
Maynard S, Min J, Merchan J, Lim K. Excess placental soluble fms-like tyrosinekinase-1 (sFlt-1) may contribute to endometrial disfunction, hypertension and proteinuria in preeclampsia. J Clin Invest. 2003;111:649-658.
Roberts JM, Bell MJ. If we know so much about preeclampsia, why haven´t we cured the desease? J Reprod Immunol 2013; 99: 1–9.
Shibata E, Rajakumar A, Roberts RW. et al. Soluble fms-like tyrosine kinase 1 is increased in preeclampsia but not in normotensive pregnancies with small-for-gestational-age neonates: relationship to circulating placental growth factor. J Clin Endocrinol Metab. 2005;90:4895-4903.
Wang A, Rana S, Karumanchi SA. Preeclampsia: the role of angiogenic factors inits pathogenesis. Physiology. 2009;24:147-158.
Yelliffe-Pawlowsky L, Shaw G, Currier R. et al. Association of early preterm birth with abnormal levels of rutinely collected ferstand second-thrimester biomarkers. Am J Obstet and Gynecol. 2013;208:128-140.
