ANALYSIS OF GIRLS' HEALTH PROBLEMS IN ADOLESCENCE AND PREDICTION OF PCOS
Keywords:
PCOS, hyperandrogenemia, acne, anovulation, insulin resistance, obesity, body mass index.Abstract
The relevance of the study of reproductive health and risk assessment of polycystic ovary syndrome (PCOS) is related to the fact that this disease is a common cause of infertility, and is also a global somatic health problem, including disorders of the endocrine-metabolic status, cardiovascular diseases and has a high oncological risk. The aim of the study is to evaluate the results of clinical and anamnestic indicators that contribute to the development of PCOS in adolescent girls. The study included 182 adolescent girls from 13 to 17 years old, who were interviewed with questionnaires that reflected such health issues as the characteristics of menstrual function, metabolic disorders, genetic predisposition to diabetes mellitus and arterial hypertension. The degrees of development of the mammary glands were also assessed according to the Tanner scale and the degree of hirsutism according to the Ferriman-Gallwey scale. Thus, according to the results of the study, it is clear that half of the adolescent girls in Tashkent suffer from algomenorrhea syndrome. Our region is also prone to anemia due to the monthly loss of large amounts of blood. It should be noted that almost half of the girls have intermenstrual bleeding, which may be associated with an unsettled menstrual cycle, but this is observed in every second girl. As is known, theoretically, thelarche occurs a year earlier than menarche. Our studies have confirmed the results of previous studies. More than half of the girls assess their skin condition as unsatisfactory, noting acne, which is considered a physiological norm, but this is
not satisfactory and leads to depression. Of particular note is the burden of diabetes mellitus and arterial hypertension in relatives. Most girls suffer from hirsutism. The onset of puberty is a critical moment in the development of PCOS and early intervention is, in the opinion of researchers in recent years, mandatory.
References
Лукьянова Д.М., Хищенко Е.П., Уварова Е.В. Молекулярно-генетические аспекты формирования фенотипов синдрома
поликистозных яичников у девочек-подростков. Репродуктивное здоровье детей и подростков]. 2015; (5): 46-55.
Azziz, R. Task Force on the Phenotype of the Polycystic Ovary Syndrome of The Androgen Excess and PCOS Society. The Androgen
Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report // Fertility and Sterility. – 2009. – Vol.
– P. 456–48.
Donbaloğlu, Z. Hyperandrogenism correlates with psychological symptoms in adolescents with polycystic ovary syndrome // Clin Pediatr
Endocrinol. – 2022. – Vol. 31. – P. 68–76.
Imran, H.J. Testosterone or Dehydroepiandrosterone Sulfate as A Biomarker for Hirsutism in Women with Polycystic Ovary Syndrome //
Biomedical & Pharmacology Journal. – 2020. – Vol. 13. – P. 1815–1823.
№3 | 2024
Sanchez-Garrido, M.A. Metabolic dysfunction in polycystic ovary syndrome: Pathogenic role of androgen excess and potential therapeutic
strategies / M.A. Sanchez-Garrido, M. Tena-Sempere // Molecular Metabolism. – 2020. – Vol. 35. – P. 1–16.
Stepto, N.K. Women with polycystic ovary syndrome have intrinsic insulin resistance on euglycaemichyperinsulaemic clamp. // Hum
Reprod. – 2013. – Vol. 28. – P. 777–784.
Teede, H. International Evidence-based Guideline for the assessment and management of polycystic ovary syndrome 2023. – Melbourne:
Monash University, 2023. – 258 p.
Teede, H. International evidence-based guideline for the assessment and management of polycystic ovary syndrome 2018 / H. Teede [et
al.]. – Melbourne: Monash University, 2018. – 198 p.