BOLALAR SEREBRAL FALAJIDA BOTULINOTERAPIYADAN SO‘NG SKELET MUSHAGINING STRUKTURAVIY VA FUNKSIONAL QAYTA TUZILISHI (klinik-fiziologik tadqiqot)
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bolalar serebral falaji, botulinoterapiya, skelet mushagi, strukturaviy va funksional remodellashtirish, EMG, spastiklik##article.abstract##
Ushbu tadqiqotning maqsadi bolalar serebral falajida (BSF) botulinoterapiyadan so‘ng skelet mushagida yuzaga keladigan strukturaviy va funksional o‘zgarishlarni klinik, elektrofiziologik hamda funksional ko‘rsatkichlar asosida o‘rganishdan iborat. Spastiklik dinamikasi, harakat funksiyasi va nishon mushaklarning elektromiografik xususiyatlari botulin toksini A turini yuborishdan oldin va keyin baholangan holda prospektiv klinik-fiziologik tadqiqot o‘tkazildi. Olingan ma’lumotlar botulinoterapiya skelet mushagida patologik faollikning kamayishi, mushaklararo koaktivatsiyaning pasayishi va funksional qayta tuzilishni o‘z ichiga olgan murakkab remodellashtirish jarayonlarini boshlab berishini ko‘rsatdi. Bu esa harakat naqshlarini tiklash va reabilitatsiya samaradorligini oshirish uchun qulay sharoitlar yaratadi.Библиографические ссылки
Rosenbaum P., Paneth N., Leviton A., et al. A report: The definition and classification of cerebral palsy, April 2006. Developmental Medicine & Child Neurology Supplement. 2007;109:8–14.
Graham H.K., Selber P. Musculoskeletal aspects of cerebral palsy. Journal of Bone and Joint Surgery. British Volume. 2003;85(2):157–166.
Gracies J.M. Pathophysiology of spastic paresis. I: Paresis and soft tissue changes. Muscle & Nerve. 2005;31(5):535–551.
Gracies J.M. Pathophysiology of spastic paresis. II: Emergence of muscle overactivity. Muscle & Nerve. 2005;31(5):552–571.
Lieber R.L., Fridén J. Spasticity causes a fundamental rearrangement of muscle–joint interaction. Muscle & Nerve. 2002;25(2):265–270.
Smith L.R., Lee K.S., Ward S.R., et al. Hamstring contractures in children with spastic cerebral palsy result from a stiffer extracellular matrix and increased in vivo muscle tension. Journal of Physiology. 2011;589(10):2625–2639.
Aoki K.R. Pharmacology and immunology of botulinum toxin serotypes. Journal of Neurology. 2001;248(Suppl 1):3–10.
Dressler D., Adib Saberi F. Botulinum toxin: Mechanisms of action. European Neurology. 2005;53(1):3–9.
Molenaers G., Desloovere K., Fabry G., et al. The effects of quantitative gait assessment and botulinum toxin type A on musculoskeletal surgery in children with cerebral palsy. Journal of Bone and Joint Surgery. American Volume. 2006;88(1):161–170.
Heinen F., Molenaers G., Fairhurst C., et al. European consensus table on the use of botulinum toxin type A in children with cerebral palsy. European Journal of Paediatric Neurology. 2006;10(5–6):215–225.
Gough M., Shortland A.P. Could muscle deformity in children with spastic cerebral palsy be related to impaired muscle growth and altered adaptation? Developmental Medicine & Child Neurology. 2012;54(6):495–499.
Williams P.E., Goldspink G. Changes in sarcomere length and physiological properties in immobilized muscle. Journal of Anatomy. 1978;127(Pt 3):459–468.
Koman L.A., Mooney J.F., Smith B.P., Walker F., Leon J.M. Botulinum toxin type A neuromuscular blockade in the treatment of spasticity in cerebral palsy: A randomized, double-blind, placebo-controlled trial. Journal of Pediatric Orthopaedics. 2000;20(1):108–115.
Henneman E., Somjen G., Carpenter D.O. Functional significance of cell size in spinal motoneurons. Journal of Neurophysiology. 1965;28(3):560–580.
Farmer S.F., Ingram D.A., Stephens J.A. Mirror movements studied in a patient with Klippel–Feil syndrome. Journal of Physiology. 1990;428:467–484.
Kandel E.R., Koester J.D., Mack S.H., Siegelbaum S.A. Principles of Neural Science. 6th ed. New York: McGraw-Hill; 2021.
Skvortsov I.A. Cerebral Palsy: Clinical Features, Diagnosis, and Treatment. Moscow: GEOTAR-Media; 2010. (In Russian)
Badalyan L.O., Zhurba L.T., Timonina O.V. Cerebral Palsy in Children. Moscow: Meditsina; 2008. (In Russian)
Gusev E.I., Zavalishin I.A. Neuroplasticity and recovery of motor functions. S.S. Korsakov Journal of Neurology and Psychiatry. 2012;112(6):4–10. (In Russian)
Khaibullina Z.R., Khabirov F.A. Electromyographic methods for assessing spasticity in cerebral palsy. Neurological Bulletin. 2016;48(3):34–40. (In Russian)
