OG’IR BOSH MIYA JAROHATLARIDA BOSH MIYA SHISHIGA QARSHI TERAPIYANI OPTIMALLASHTIRISH
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bosh miya jarohati, neyron yallig’lanishi, miya shishi, paratsetamol, Glazgo koma shkalasi, intrakranial gipertenziya##article.abstract##
Og’ir bosh miya jarohati patofiziologiyasida neyron yallig’lanishi va miya shishi markaziy o’rin tutadi. Ushbu tadqiqotda og’ir bosh miya jarohati olgan bemorlarda standart davolashga qo’shimcha ravishda paratsetamol infuziyasining samaradorligi baholandi. Tadqiqotga nazorat va asosiy guruhlarga bo’lingan 40 nafar bemor kiritildi. Asosiy guruhda yallig’lanish sitokinlari (IL-1β, IL-6, TNF-α) darajasining sezilarli darajada pasayishi, IL-10 darajasining oshishi, Glazgo koma shkalasi bo’yicha ballarning yaxshilanishi va KT ma’lumotlariga ko’ra shish hajmining kamayishi qayd etildi. Paratsetamol infuziyasini o’z ichiga olgan multimodal yondashuv og’ir bosh miya jarohati bilan og’rigan bemorlarda neyron yallig’lanishini nazorat qilish va tiklanish jarayonini tezlashtirishda istiqbolli ekanligini ko’rsatdi.
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