QIYOSIY GISTOMORFOMETRIK BAHOLASH: GEN-AKTIVLASHTIRILGAN MATERIALLARNI GEL TASHUVCHIDA EKSPERIMENTAL QO'LLASHDA SUYAK TO'QIMALARINING REGENERATSIYASI
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suyak regeneratsiyasi, gen bilan faollashtirilgan gellar, VEGF-A165, alginat geli, kollagen geli, gistomorfometrik baholash, suyak shakllanishi, biomateriallar, suyak defektlari, o'sish omillari##article.abstract##
Ushbu tadqiqotda gen bilan faollashtirilgan alginat va kollagen gellaridan foydalangan holda suyak regeneratsiyasining qiyosiy gistomorfometrik baholash amalga oshirilgan. Asosiy e'tibor VEGF-A165ning regenerat markaziy qismidagi suyak hosil bo'lish jarayoniga ta'siriga qaratilgan. Natijalar shuni ko'rsatdiki, gellarga VEGF-A165 qo'shilishi ma'lum o'sish omilisiz gellarga nisbatan suyak regeneratsiyasini sezilarli darajada yaxshilaydi. Regeneratning markaziy qismida VEGF-A165 hamda gen bilan faollashtirilgan gellardan foydalanganda, yangi hosil bo'lgan suyak to'qimalarining hajmi sezilarli darajada oshishi aniqlandi. Ushbu natijalar suyak to'qimalarining samarali regeneratsiyada VEGF-A165 ning potensiali yuqori ekanligi tasdiqlandi. Olingan natijalar yangi davolash strategiyalarini ishlab chiqish va suyak nuqsonlarini tiklashdagi klinik yondashuvlarni yaxshilash uchun muhim hisoblanadi.
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