SURUNKALI BUYRAK KASALLIGINING TURLI BOSQICHLARIDA SURUNKALI MIYA ISHEMIYASI BILAN OG‘RIGAN BEMORLARDA SLUMS VA MINI-COG SHKALALARI BO‘YICHA KOGNITIV FUNKSIYALAR
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surunkali miya ishemiyasi; surunkali buyrak kasalligi; kognitiv buzilishlar; SLUMS shkalasi; Mini-Cog##article.abstract##
Maqsad. Surunkali miya ishemiyasi (SMI) bilan og‘rigan bemorlarda kognitiv funksiyalarni surunkali buyrak kasalligi (SBK) bosqichiga qarab SLUMS va Mini-Cog shkalalari yordamida baholash.
Material va usullar. SBK 1–3a bosqichlari bo‘lgan SMI bilan og‘rigan 67 nafar bemor tekshirildi (42 nafar ayol, 25 nafar erkak; o‘rtacha yoshi 61,0±10,1 yosh). Kognitiv funksiyalar SLUMS va Mini-Cog shkalalari bo‘yicha baholandi. Guruhlar noparametrik usullar (Kraskel–Uollis, Bonferroni tuzatishli Mann–Uitni mezonlari, Spirmen korrelyatsiyasi) yordamida taqqoslandi.
Natijalar. SLUMS bo‘yicha o‘rtacha ball 22,82±1,29 ni tashkil etdi va SBK rivojlanishi bilan pasaydi: 1-bosqichda 24,00±1,03, 2-bosqichda 23,12±0,85, 3a bosqichda 21,85±1,03 (p<0,001). SBK bosqichi SLUMS bali bilan teskari korrelyatsiyaga ega bo‘ldi (ρ=−0,67; p<0,001). Mini-Cog bali (4,06±0,72) SBK bosqichiga bog‘liq bo‘lmadi (p=0,92) va buyrak funksiyasi ko‘rsatkichlari bilan korrelyatsiya qilmadi.
Xulosa. SMI bilan og‘rigan bemorlarda SLUMS bo‘yicha kognitiv buzilishlar SBKning dastlabki bosqichlaridayoq kuchayib boradi, Mini-Cog esa bu farqlarni aniqlamaydi. Bunday bemorlarda kognitiv buzilishlarni skrining qilish uchun SLUMS shkalasidan foydalanish maqsadga muvofiq.
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