COGNITIVE FUNCTION ASSESSED BY THE SLUMS AND MINI-COG SCALES IN PATIENTS WITH CHRONIC CEREBRAL ISCHEMIA AT DIFFERENT STAGES OF CHRONIC KIDNEY DISEASE
Keywords:
chronic cerebral ischemia; chronic kidney disease; cognitive impairment; SLUMS; Mini-CogAbstract
Aim. To assess cognitive function using the SLUMS and Mini-Cog scales in patients with chronic cerebral ischemia (CCI) according to the stage of chronic kidney disease (CKD).
Materials and methods. We examined 67 patients with CCI and CKD stages 1–3a (42 women, 25 men; mean age 61.0±10.1 years). Cognitive function was assessed with SLUMS and Mini-Cog. Groups were compared using nonparametric methods (Kruskal–Wallis, Mann–Whitney with Bonferroni correction, Spearman correlation).
Results. The mean SLUMS score was 22.82±1.29 and decreased with CKD progression: 24.00±1.03 in stage 1, 23.12±0.85 in stage 2 and 21.85±1.03 in stage 3a (p<0.001). CKD stage correlated inversely with the SLUMS score (ρ=−0.67; p<0.001). The Mini-Cog score (4.06±0.72) did not depend on CKD stage (p=0.92) and did not correlate with kidney function parameters.
Conclusion. In patients with CCI, SLUMS reveals a decline in cognition already in the early stages of CKD, whereas Mini-Cog does not detect these differences. SLUMS appears more suitable for cognitive screening in this population.
References
Etgen T., Chonchol M., Förstl H., Sander D. Chronic kidney disease and cognitive impairment: a systematic review and meta-
analysis // Am J Nephrol. 2012. Vol. 35, № 5. P. 474–482.
Bugnicourt J.M., Godefroy O., Chillon J.M., Choukroun G., Massy Z.A. Cognitive disorders and dementia in CKD: the neglected kidney-brain axis // J Am Soc Nephrol. 2013. Vol. 24, № 3. P. 353–363.
Lu R., Kiernan M.C., Murray A., Rosner M.H., Ronco C. Kidney-brain crosstalk in the acute and chronic setting // Nat Rev
Nephrol. 2015. Vol. 11, № 12. P. 707–719.
Borson S., Scanlan J., Brush M., Vitaliano P., Dokmak A. The Mini-Cog: a cognitive «vital signs» measure for dementia screening in multi-lingual elderly // Int J Geriatr Psychiatry. 2000. Vol. 15, № 11. P. 1021–1027.
Tariq S.H., Tumosa N., Chibnall J.T., Perry M.H. 3rd, Morley J.E. Comparison of the Saint Louis University mental status examination and the mini-mental state examination for detecting dementia and mild neurocognitive disorder — a pilot study // Am J Geriatr Psychiatry. 2006. Vol. 14, № 11. P. 900–910.
Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2024 clinical practice guideline for the
evaluation and management of chronic kidney disease // Kidney Int. 2024. Vol. 105, № 4S. P. S117–S314.
Kurella Tamura M., Wadley V., Yaffe K., McClure L.A., Howard G., Go R., Allman R.M., Warnock D.G., McClellan W. Kidney function and cognitive impairment in US adults: the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study // Am J Kidney Dis. 2008. Vol. 52, № 2. P. 227–234.
Watanabe K., Watanabe T., Nakayama M. Cerebro-renal interactions: impact of uremic toxins on cognitive function // Neurotoxicology. 2014. Vol. 44. P. 184–193.
Seitz D.P., Chan C.C., Newton H.T., Gill S.S., Herrmann N., Smailagic N., Nikolaou V., Fage B.A. Mini-Cog for the detection of dementia within a primary care setting // Cochrane Database Syst Rev. 2021. Issue 7. CD011415.
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