ПАРКИНСОН КАСАЛЛИГИДА ДОФАМИН ЙЕТИШМОВЧИЛИГИ ВА УНИНГ ХАРАКАТГА ТАЬСИРИ
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Паркинсон касаллиги,допамин,ДОФАЛ нейротоксиклиги, алфа-синуклеин##article.abstract##
Паркинсон касаллиги(ПК) мотор ва когнитив функцияларга таьсир килувчи прогрессив нейродегенератив касалликдир.Паркинсон касаллиги этиологиясида генетик ва атроф мухит омиллари мухим рол уйнайди.Нейротрансмиттер допамин харакатни,мотивацияни,хотирани ва бошка физиологик жараёнларни тартибга солишдаиштирок этади.Паркинсон касаллиги билан оғриган одамларда допаминергик нейронларнинг йуколиши допамин даражасининг пасайишига олиб келади ва беморларда кузатиладиган когнитив нуксонларни келтириб чикарди.Сўнгги 50 йил ичида Паркинсон касаллигини даволаш,этиологияси ва патогенезида мухим ютуқлалга эришилди.ПК билан огриган беморларда дофаминнинг камайиб кетиши мумкин бўлган турли механизмларини,масалан,алфа-синуклеин аномалиялари,митохондриал дисфункция ва 3,4-дигидросифенилатсеталдегид (ДОФАЛ) токсиклиги ва бошқалар.
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