ДЕФИЦИТ ДОФАМИНА ПРИ БОЛЕЗНИ ПАРКИНСОНА И ЕГО ВЛИЯНИЕ НА ДВИЖЕНИЕ
Ключевые слова:
болезнь Паркинсона, дофамин, нейротоксичность ДФА, альфа-синуклеинАннотация
Болезнь Паркинсона (БП) — прогрессирующее нейродегенеративное заболевание, поражающее двигательные и когнитивные функции. Генетика и факторы окружающей среды играют важную роль в этиологии болезни Паркинсона. Нейромедиатор дофамин участвует в регуляции движения, мотивации, памяти и других физиологических процессов. У людей с болезнью Паркинсона потеря дофаминергических нейронов приводит к снижению уровня дофамина и вызывает наблюдаемые у пациентов когнитивные нарушения. Были изучены различные механизмы снижения уровня дофамина у пациентов с болезнью Паркинсона, такие как нарушения альфа- синуклеина, митохондриальная дисфункция и токсичность 3,4-дигидрофенилацетальдегида (ДФА).
Библиографические ссылки
. GBD 2016 Parkinson’s Disease Collaborators (2018) Global, regional, and national burden of Parkinson’s disease, 1990–2016: A systematic analysis for the Global Burden of Disease Study 2016, Lancet Neurol 17, 939–953. [DOI] [PMC free article] [PubMed] [Google Scholar] [2]. Dong-Chen X, Yong C, Yang X, Chen-Yu S, Li-Hua P (2023) Signaling pathways in Parkinson’s disease: Molecular mechanisms and
therapeutic interventions. Signal Transduct Target Ther 8, 73. [DOI] [PMC free article] [PubMed] [Google Scholar]
. Fereshtehnejad S-M, Ghazi L, Shafieesabet M, Shahidi GA, Delbari A, Lökk J (2014) Motor, psychiatric and fatigue features associated with nutritional status and its effects on quality of life in Parkinson’s disease patients, PLoS One 9, e91153. [DOI] [PMC free article] [PubMed] [Google Scholar]
. Palavra NC, Lubomski M, Flood VM, Davis RL, Sue CM (2021) Increased added sugar consumption is common in Parkinson’s disease.
Front Nutr 8, 628845. [DOI] [PMC free article] [PubMed] [Google Scholar]
. Simon N, Gantcheva R, Bruguerolle B, Viallet F (2004) The effects of a normal protein diet on levodopa plasma kinetics in advanced Parkinson’s disease. Parkinsonism Relat Disord 10, 137–142. [DOI] [PubMed] [Google Scholar]
. Rusch C, Flanagan R, Suh H, Subramanian I (2023) To restrict or not to restrict? Practical considerations for optimizing dietary protein interactions on levodopa absorption in Parkinson’s disease. NPJ Parkinsons Dis 9, 98. [DOI] [PMC free article] [PubMed] [Google Scholar]
. Kacprzyk KW, Milewska M, Zarnowska A, Panczyk M, Rokicka G, Szostak-Wegierek D (2022) Prevalence of malnutrition in patients with Parkinson’s disease: A systematic review. Nutrients 14, 5194. [DOI] [PMC free article] [PubMed] [Google Scholar]
. Sheard JM, Ash S, Mellick GD, Silburn PA, Kerr GK (2013) Markers of disease severity are associated with malnutrition in Parkinson’s disease, PLoS One 8, e57986. [DOI] [PMC free article] [PubMed] [Google Scholar]
. Sheard JM, Ash S, Mellick GD, Silburn PA, Kerr GK (2014) Improved nutritional status is related to improved quality of life in Parkinson’s disease. BMC Neurol 14, 212. [DOI] [PMC free article] [PubMed] [Google Scholar]
. Krikorian R, Shidler MD, Summer SS, Sullivan PG, Duker AP, Isaacson RS, Espay AJ (2019) Nutritional ketosis for mild cognitive impairment in Parkinson’s disease: A controlled pilot trial. Clin Park Relat Disord 1, 41–47. [DOI] [PMC free article] [PubMed] [Google Scholar] [11].Damier P, Hirsch EC, Agid Y, Graybiel AM. The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons
in Parkinson's disease. Brain. 1999;122( Pt 8):1437–1448. doi: 10.1093/brain/122.8.1437. [DOI] [PubMed] [Google Scholar]
.Bjorklund A, Dunnett SB. Dopamine neuron systems in the brain: an update. Trends Neurosci. 2007;30:194–202. doi: 10.1016/j.tins.2007.03.006. [DOI] [PubMed] [Google Scholar]
.Chaudhuri KR, Schapira AH. Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment. Lancet Neurol.
;8:464–474. doi: 10.1016/S1474-4422(09)70068-7. [DOI] [PubMed] [Google Scholar]
.Krack P, Hariz MI, Baunez C, Guridi J, Obeso JA. Deep brain stimulation: from neurology to psychiatry? Trends Neurosci. 2010;33:474–
doi: 10.1016/j.tins.2010.07.002. [DOI] [PubMed] [Google Scholar]
.Thobois S, et al. Non-motor dopamine withdrawal syndrome after surgery for Parkinson's disease: predictors and underlying mesolimbic denervation. Brain. 2010;133:1111–1127. doi: 10.1093/brain/awq032. [DOI] [PubMed] [Google Scholar]
