DEGENERATIV VA TOMIR PARKINSONIZMIDA "ICHAK–BOSH MIYA" O‘QI FAOLIYATINING NOZOLOGIYALARARO MARKERI SIFATIDA ZARDOBDAGI INTERLEYKIN-6 DARAJASI
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Parkinson kasalligi, tomir parkinsonizmi, interleykin-6, «ichak–bosh miya» o‘qi, Helicobacter pylori, fekal kalprotektin, nomotor simptomlar, qiyosiy tashxislash##article.abstract##
Maqolada parkinsonizmning degenerativ va vaskulyar shakllari bo‘lgan bemorlarda tizimli yallig‘lanish javobini o‘rganishga bag‘ishlangan qiyosiy klinik-laborator tadqiqot natijalari keltirilgan. Immun faollashuvning asosiy markeri sifatida zardobdagi interleykin-6 konsentratsiyasi kasallikning klinik namoyon bo‘lishi va me'da-ichak tizimining trigger omillari, masalan, Helicobacter pylori invaziyasi va subklinik enteral yallig‘lanish bilan o‘zaro bog‘liqlikda o‘rganilgan. Tadqiqot davomida o‘rganilayotgan guruhlar o‘rtasida korrelatsiya aloqalari arxitekturasining sifat jihatdan qutbliligi aniqlandi. Parkinson kasalligi bilan og‘rigan bemorlarda tizimli yallig‘lanish darajasi gastroduodenal sohaning infeksion obsemeneniyasi, ichak shilliq qavati mahalliy immun javobining yaqqolligi, shuningdek, harakat va nomoror tanqisligining og‘irligi bilan qat'iy bog‘liqlikni ko‘rsatdi. Aksincha, tomir parkinsonizmi bo‘lgan bemorlar kohortasida tsitokin darajasi o‘rganilgan parametrlar spektriga, shu jumladan gastrointestinal triggerlarga nisbatan butunlay indifferent bo‘lib chiqdi. Tomir parkinsonizmida tsitokinemiya avtonom vazogen xususiyatga ega va surunkali serebral ishemiya bilan belgilanadi, degan xulosaga kelindi. Yallig‘lanish va enteral markerlarning o‘zaro bog‘liqligini baholash nozologiyalararo qiyosiy tashxislash uchun ma'lumot beruvchi qo‘shimcha mezon sifatida foydalanish uchun tavsiya etiladi.
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