SERUM INTERLEUKIN-6 LEVEL AS AN INTER-NOSOLOGICAL MARKER OF THE "GUT-BRAIN" AXIS ACTIVITY IN DEGENERATIVE AND VASCULAR PARKINSONISM

Abstract

The article presents the results of a comparative clinical and laboratory study focusing on the systemic inflammatory response in patients with degenerative and vascular forms of parkinsonism. Serum interleukin-6 concentration was investigated as the primary marker of immune activation in relation to clinical manifestations and gastrointestinal triggers, including Helicobacter pylori invasion and subclinical enteral inflammation. The study revealed a qualitative polarity in the architecture of correlation profiles between the examined cohorts. In patients with Parkinson's disease, the level of systemic inflammation demonstrated a tight linkage with the infectious burden of the gastroduodenal zone, the intensity of the local immune response of the intestinal mucosa, and the severity of both motor and non-motor deficits. Conversely, in the cohort of patients with vascular parkinsonism, the cytokine level was completely indifferent to the entire spectrum of the parameters studied, including gastrointestinal triggers.The findings scientifically substantiate the nosological specificity and selective activation of the functional "gut-brain" axis exclusively for the degenerative process in Parkinson's disease. It is concluded that in vascular parkinsonism, cytokinemia has an autonomous vasogenic nature and is determined by chronic cerebral ischemia. Assessing the conjunction of inflammatory and enteral markers is recommended as an informative supplementary criterion for inter-nosological differential diagnosis.