ROLE OF THE COMPLEMENT SYSTEM IN THE DEVELOPMENT OF DIABETIC POLYNEUROPATHY
Keywords:
complement system, diabetic polyneuropathy, membrane attack complexAbstract
Aim. To analyze the roles of complement components in the development of diabetic polyneuropathy
Material and methods. We selected patients who were undergoing treatment with a diagnosis of type 2 diabetes with grade 2 DPN. In the main group there were 46 patients (24 women and 22 men; average age of patients 56±8 years), and in the control group there were 38 practically healthy individuals without heredity burdened with diabetes (20 women, 18 men; average age 51±10 years ). In the main group, the duration of type 2 diabetes was on average 12±8 years, and the duration of DPN was on average 9±5 years.
Results. We assessed the clinical forms of DPN using the TSS, NSS and NDS scales. According to the results, out of 46 (100%) patients in the main group, 12 (26%) had sensory DPN, 14 (30%) had motor DPN, and 20 (44%) had sensorimotor DPN. The total amount of complement component C3 in the blood serum of patients in the main group was 11.1±2.1 ng/ml. This indicator in the blood serum of healthy controls was 1.8±0.9 ng/ml. Levels of factor C3 were 6.9±2.4 ng/ml in sensory DPN, 9.8±2.6 ng/ml in motor DPN and 16.7±2.7 ng/ml in sensorimotor DPN.
Conclusion. A high level of complement component C3 in the blood serum leads to activation of the membrane attack complex. This, in turn, causes the accumulation of intermediate products in the wall of endoneurial microvessels, leading to an increase in permeability and narrowing of blood vessels, deepening degenerative processes.
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Муаллифларнинг маълумотлари / Информация об авторах / Information about the authors
КОНТАКТНАЯ ИНФОРМАЦИЯ:
Матмуродов Рустамбек Жуманазарович – доктор медицинских наук, профессор кафедры Неврологии и медицинкой психологии ТМА, г.Ташкент, Республика Узбекистан
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Финансирование. Исследование не имело спонсорской поддержки (собственные ресурсы).
