PREDICTING CLINICAL OUTCOMES OF HEMORRHAGIC STROKE BASED ON ACUTE PHASE BIOMARKERS
Keywords:
Hemorrhagic stroke, ICAM-1, VCAM-1, GDNF, VEGF, adhesion molecules, neuroplasticity, angiogenesisAbstract
Biomarkers of the acute phase of hemorrhagic stroke are objective biochemical parameters that reflect the intensity of pathophysiological processes in the early days of the disease and have the potential to predict long-term outcomes. In this study, a comprehensive analysis of the prognostic value of sICAM-1, sVCAM-1, GDNF, VEGF concentrations at various time points of the acute period was performed to predict mortality, functional outcomes, and the development of complications. The results of the study shoved that in order to predict the outcome of hemorrhagic stroke, it is advisable to determine the levels of these markers in the blood serum, since they have a high prognostic value as an individual. This is also the case as part of combined models, providing accurate risk stratification, early detection of complications, and the possibility of personalization.
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