PERSONALIZED EARLY REHABILITATION AFTER MECHANICAL THROMBECTOMY: IMPACT ON FUNCTIONAL OUTCOMES
Keywords:
ischemic stroke, mechanical thrombectomy, early rehabilitation, personalized rehabilitation, functional outcomes, neuroplasticity, NIHSS, ASPECTS, modified Rankin Scale, Barthel Index, Functional Independence MeasureAbstract
Ischemic stroke remains one of the leading causes of mortality, disability, and long-term loss of functional independence worldwide. Despite major advances in endovascular treatment, particularly the widespread use of mechanical thrombectomy in patients with large vessel occlusion, clinical outcomes after technically successful reperfusion remain heterogeneous. This underscores the need to identify additional therapeutic factors capable of enhancing neurological recovery during the hyperacute and early recovery phases. The aim of the present study was to evaluate the impact of personalized early rehabilitation initiated within the first 24–48 hours after mechanical thrombectomy on functional outcomes in patients with acute ischemic stroke. The study was designed as a prospective cohort analysis and included 132 patients who underwent mechanical thrombectomy for anterior circulation large vessel occlusion. The patients were divided into two groups depending on the timing of rehabilitation onset: an early rehabilitation group and a delayed rehabilitation group. Clinical efficacy was assessed using the NIHSS, ASPECTS, modified Rankin Scale, Barthel Index, and Functional Independence Measure. The findings demonstrated that personalized early rehabilitation was associated with a higher rate of favorable functional outcomes by day 90, better performance in activities of daily living, and a higher overall level of functional independence. The most pronounced benefit was observed in patients with ASPECTS ≥7 and NIHSS ≤14. These results indicate that early, structured, and individualized rehabilitation after mechanical thrombectomy is a safe and clinically effective strategy that may reduce disability, decrease complications related to prolonged immobilization, and improve overall treatment outcomes in acute ischemic stroke. Integration of personalized rehabilitation pathways into comprehensive stroke care may further optimize post-thrombectomy recovery and support better long-term neurological prognosis.
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