CADASIL va disirkulyator ensefalopatiyada kognitiv buzilishlarning klinik va neyrovizual farqlanishi
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CADASIL, disirkulyator ensefalopatiya, kognitiv buzilish, MRT##article.abstract##
Kirish. CADASIL irsiy serebral mikroangiopatiya, disirkulyator ensefalopatiya esa surunkali serebrovaskulyar yetishmovchilik sifatida kognitiv buzulishlarga olib keluvchi kasalliklardir. Ushbu tadqiqotning maqsadi CADASIL va disirkulyator ensefalopatiya bemorlarida kognitiv buzilishlarning klinik va neyrovizual xususiyatlarini qiyosiy baholashdan iborat.
Material va metodlar. Kesimiy tadqiqotga 106 nafar ishtirokchi kiritildi: 31 nafar CADASIL bemori, 45 nafar disirkulyator ensefalopatiya bemori va 30 nafar sog‘lom nazorat guruhi. Barcha ishtirokchilarda klinik-nevrologik tekshiruv, neyropsixologik testlar hamda bosh miya MRT tekshiruvlari o‘tkazildi. Oq modda zararlanishlari Fazekas shkalasi asosida baholandi.
Natijalar. CADASIL guruhida SDMT ko‘rsatkichlari nazorat guruhiga nisbatan sezilarli darajada past bo‘ldi (33.8 ± 7.1 va 48.6 ± 6.3; p < 0.001). Disirkulyator ensefalopatiya guruhida SDMT natijalari 38.9 ± 8.4 ni tashkil etdi. Fazekas ≥2 darajadagi oq modda zararlanishlari CADASIL guruhida 74.2 % bemorda, disirkulyator ensefalopatiya guruhida esa 51.1 % bemorda aniqlandi (p = 0.03). Oldingi chakka pushtasi zararlanishlari CADASIL bemorlarining 45.2 % ida, tashqi kapsula zararlanishlari esa 41.9 % ida kuzatildi, DE guruhida bu ko‘rsatkichlar mos ravishda 13.3 % va 17.8 % ni tashkil etdi (p < 0.05).
Xulosa. CADASIL bemorlarida kognitiv buzilishlar disirkulyator ensefalopatiyaga nisbatan ancha yaqqol namoyon bo‘lib, MRTda oldingi chakka pushtasi va tashqi kapsula hududlaridagi zararlanishlar ko‘proq uchradi.
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