THE ROLE OF BLOOD-BRAIN BARRIER DAMAGE AND INTERCELLULAR ADHESION IN THE DEVELOPMENT OF COGNITIVE DISORDERS IN TYPE II DIABETES MELLITUS
Keywords:
type II diabetes mellitus, blood-brain barrier, intercellular adhesion, cognitive disorders, neurodegeneration, endothelial dysfunction, neuroinflammation, oxidative stressAbstract
One of the main factors leading to the development of cerebrovascular diseases are endocrinopathies. Among them, CT is one of the most common diseases accompanied by cerebrovascular disorders. Statistical studies over the last 10 years show that the cause of death in 10% of type 2 CT patients is related to cerebrovascular disorders. CT is accompanied by metabolic and morphofunctional changes in the cranium leading to diabetic encephalopathy followed by cognitive, motor, sensorimotor and psychoemotional disorders.
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