DYNAMICS OF THE CYTOKINE PROFILE OF THE ORAL FLUID IN PATIENTS WITH SETTON'S APHTHOSIS
Keywords:
cytokine profilе, cytokine mechanism, T-lymphocytes, various interleukins, oral fluid, inflammatory response, TNF-a, IL-2, IL-12, IL-10Abstract
Diseases of the oral mucosa are one of the most complex, urgent problems of dentistry and so far, they are the least studied in terms of etiology, pathogenesis, diagnosis and especially treatment among other dental diseases. It is known that the development of aphthae is provoked by stimulation of COP keratinocytes by an unknown antigen, which, in turn, leads to the stimulation of T-lymphocytes and the release of cytokines and various interleukins. TNF-α is a major pro-inflammatory cytokine that has a chemotactic effect on neutrophils, stimulating the inflammatory cascade. Abnormalities in the cytokine mechanism (namely, increased levels of TNF-a, IL-2, IL-12 and decreased levels of IL-10) accelerate LPO, while reducing the ability of antioxidant defense mechanisms, which greatly increases oxidative stress. Due to the decrease in the concentration of IL-10, which acts to inhibit the release of cytokines, the inflammatory response is not suppressed, which leads to the development of the clinical picture of PAC. Modern ideas about the pathogenesis of AS note a significant role of cytokine profile imbalance in the occurrence and clinical manifestation of the pathology under study.
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