BOLALAR VA O‘SMIRLARDA HELICOBACTER PYLORINING ANTIBIOTIKLARGA REZISTENTLIGI: ZAMONAVIY MUAMMOLAR VA ERADIKATSION TERAPIYAGA MINTAQAVIY YONDASHUVLAR
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Helicobacter pylori; antibiotiklarga rezistentlik; klaritromitsin; levofloksatsin; eradikatsion terapiya; kvadroterapiya; mintaqaviy protokollar; individual davolash; gastroenterologiya; antibiotiklarga chidamlilik; bolalar va o‘smirlar.##article.abstract##
Helicobacter pylori eng keng tarqalgan surunkali infeksiyalardan biri bo‘lib, oshqozon-ichak trakti kasalliklarining muhim sabablaridan hisoblanadi, jumladan surunkali gastrit, yara kasalligi va oshqozon saratoni. Infeksiya butun dunyo bo‘ylab keng tarqalgan bo‘lib, ko‘pincha bolalik va o‘smirlik davrida yuqtiriladi va uzoq muddat saqlanib qolishi bilan tavsiflanadi, bu esa uning muhim tibbiy va ijtimoiy ahamiyatini belgilaydi. So‘nggi yillarda H. pylori ning antibiotiklarga, ayniqsa klaritromitsin va levofloksatsinga nisbatan rezistentligi ortib borayotgani kuzatilmoqda, bu esa standart eradikatsion terapiya sxemalarining samaradorligini pasayishiga olib kelmoqda. Maqolada dunyoning turli mintaqalarida bolalar va o‘smirlar orasida rezistent H. pylori shtammlarining tarqalishi bo‘yicha zamonaviy ma’lumotlar tahlil qilingan. Terapiya samaradorligini oshirish va rezistentlikning oldini olish maqsadida mikroorganizmlarning antibiotiklarga sezuvchanligini baholashga asoslangan mintaqaviy moslashtirilgan hamda individual davolash sxemalarini qo‘llash zarurligi asoslab berilgan.
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