EKPEREMENTAL HAYVONLARDA YURAK HUJAYRALARI VA QON TOMIRLARI TUZILISHIDAGI MORFOLOGIK O‘ZGARISHLARNI O‘RGANISH UCHUN KLINIKADAN OLDINGI JARAYONDA REVMATOID ARTRIT MEXANIZMLARNI ISHLAB CHIQISH
##article.subject##:
Revmatoid artrit, yurak-qon tomir xavfi, oldini olish##article.abstract##
Tadqiqot maqsadi: ekperemental hayvonlarda yurak hujayralari va qon tomirlari tuzilishidagi morfologik o‘zgarishlarni o‘rganish uchun klinikadan oldingi jarayonda revmatoid artrit mexanizmlarni ishlab chiqish.
Materiallar va usullar. Revmatoid artrit uchun to‘liq Freund 100 ta oq randomizasiyalangan kalamushlar Buxoro davlat tibbiyot institutining vivarium stasionar sharoitida 18 oydan 24 oygacha tekshirilgan.
Natijalar va munorazalar: Eksperemental hayvonlarda yurak hujayralari va qon tomrlari tuzilishidagi morfologik o‘zgarishlarini o‘rganish uchun revmatoid artrit mexanizmlarini dori darmonlarni ishlab chiqishning klinikadan oldingi jarayonini o‘rganishdan test usulida autoimmun kasalliklar rivojlanmaydi. Revmatoid artrit kabi artrit modellarning ajralmas cheklovi hisoblanib, natijalar shuni ko‘rsatdiki zamonaviy biologik preparatlardan foydalangan holda zamonaviy terapevtik yondashuvlar RA bilan og‘rigan bemorlarning ko‘pchiligida, shu jumladan og‘ir rivojlangan bemorlarda juda muvaffaqiyatli va samarali hisoblanadi.
Xulosa. Modulyasiyalangan revmatoid artritning yurakka ta'siri mavjudligi aniqlandi va bu ushbu patologiyaning organizm uchun yetarli darajada xavf mavjudligini ko‘rsatishga imkon yaratdi.
Библиографические ссылки
Agca R., Heslinga S.C., Rollefstad S. (2017) EULAR recommendations for cardiovascular disease risk management in patients with rheumatoid arthritis and other forms of infl ammatory joint
disorders: 2015/2016 update. Ann Rheum Dis., 76 (1), pp. 17–28.
Piepoli M.F, Hoes A.W, Agewall S, Albus C, Brotons C. (2016) 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and byinvited experts). Europ Heart J, 37(29), pp. 2315–2381.
Arida A., Protogerou A.D., Kitas G.D., Sfi kakis P.P. (2018) Systemic Infl ammatory Response and Atherosclerosis: The Paradigm of Chronic Infl ammatory Rheumatic Diseases. Int J Mol Sci., 19 (7),p. 1890.
Francula-Zaninovic S., Nola I.A. (2018) Management of Measurable Variable Cardiovascular Disease Risk Factors. Curr Cardiol Rev., 14 (3), pp. 153–163.
Cooney M.T, Vartiainen E, Laatikainen T, De Bacquer D, McGorrian C.(2012) Cardiovascular risk age: concepts and practicalities. Heart, 98, pp. 941–946.
England B.R., Thiele G.M., Anderson D.R., Mikuls T.R. (2018) Increased cardiovascular risk inrheumatoid arthritis: mechanisms and implications. BMJ, 23, p. 361.
Berger J.S., Jordan C.O., Lloyd-Jones D., Blumenthal R.S.(2010) Screening for Cardiovascular Risk in Asymptomatic Patients J Am Coll Cardiol, 55, pp. 1169–77.
Karmali K.N., Persell S.D., Perel P. (2017) Risk scoring for the primary prevention of cardiovascular disease. Cochrane Database of Systematic Reviews, issue 3. Art. No.: CD00688.
Kamilova U.K, Saidova M.M.(2019) Assessment of Cardiovascular Risk in Patients with Rheumatoid Arthritis Journal of "Cardiology in Belarus", 2019, volume 11, № 4, pp. 614–619
Willis A., Davies M., Yates T., Khunti K. (2012) Primary prevention of cardiovascular disease using validated risk scores: a systematic review. Journal of Royal Society of Medicine, 105 (8), pp. 348–56.
Crowson C.S., Gabriel Sh.E., Semb A.G. (2018) Rheumatoid arthritis-specifi c cardiovascular risk scores are not superior to general risk scores: a validation analysis of patients from seven
countries. Swiss Med Wkl, 22, p. 148.
Ташкенбаева Э. Н. и др. Механизмы кардиозащитных эффектов десфлурана и севофлурана во время реперфузии //Журнал кардиореспираторных исследований. – 2021. – Т. 2. – №. 2.
Абдиева Г. А. и др. Особенности течения ишемической болезни сердца в сочетании с климактерической кардиопатией //Наука и образование: проблемы и стратегии развития. – 2017. – Т. 2. – №. 1. – С. 26-29.
