FIBROBBLASTLARNING O`SISH OMILI
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fibroblast o'sish omili, fibroblast o'sish omili retseptorlarini (FGFRs), autokrin, intrakrin, parakrin omillar, rivojlanish nuqsonlari, angiogenez, differentsiatsiya, neyrogenez##article.abstract##
Fibroblastlarning o'sish omili yoki FGF angiogenez, yaralarni davolash va embrion rivojlanishda ishtirok etadigan o'sish omillari oilasiga tegishlidir. Fibroblast o'sish omillari geparinni bog'laydigan oqsillardir. Hujayra yuzasi proteoglikanlari bilan o'zaro ta'sir qilish fibroblast o'sish omillarining signal uzatilishi uchun zarur ekanligi isbotlangangan. Fibroblast o'sish omillari keng doiradagi hujayralar va to'qimalarni proliferasiya va differensirovkasida asosiy rol o'ynaydi. Odamlarda FGF oilasining 22 vakili topilgan, ularning barchasi tizimli ravishda o'xshash signalli molekulalardir.
FGF21 - barcha sabablarga ko'ra o'limni, hamda yurak-qon tomir kasalliklaridan o'lim bashorat qilish imkonini beradi. Shu bilan birga, FGF21 ning miqdori yuqori bo`lsa, 30 kun ichida takroriy miokard infarkt kuzatilishi mumkinligi xavfi oshadi.
Библиографические ссылки
Soliyev A.U. /Qari va keksalarda arterial gipertoniya tarqalishi va xavf omillarining uchrashi. //Biomeditsina va amaliyot jurnali. B.435-441. Maxsus son. 2020 yil. Toshkent.
Degirolamo C., Sabbà C., Moschetta A. Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23 (англ.) // Nat. Rev. Drug Discov.. - 2016. — Vol. 15. — P. 51—69. — doi:10.1038/nrd.2015.9.
Armelin H. A. Pituitary extracts and steroid hormones in the control of 3T3 cell growth (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 1973. — September (vol. 70, no. 9). — P. 2702—2706. — doi:10.1073/pnas.70.9.2702. — Bibcode: 1973PNAS...70.2702A. — PMID 4354860.
https://www.ncbi.nlm.nih.gov/pubmed/20581332, Zechel S, Werner S, Unsicker K, von Bohlen und Halbach O. 2010. Expression and functions of fibroblast growth factor 2 (FGF-2) in hippocampal formation. Neuroscientist 16: 357—373.
Staiger H, Keuper M, Berti L et al. Fibroblast growth factor 21-metabolic role in mice and men. Endocrine Rev 2017; 38 (5): 468–88. DOI: 10.1210/er.2017.
Choi JR et al. Serum fibroblast growth factor 21 and new-onset metabolic syndrome: KoGES-ARIRANG study. Yonsei Med J 2018; 59 (2): 287–93. DOI: 10.3349/ymj.2018.59.2.287
Bobbert T et al. Fibroblast growth factor 21 predicts the metabolic syndrome and type 2 diabetes in Caucasians. Diabetes Care 2013; 36 (1): 145–9. DOI: 10.2337/dc12-0703
Chen C et al. High plasma level of fibroblast growth factor 21 is an independent predictor of type 2 diabetes: A 5.4-year population-based prospective study in Chinese subjects. Diabetes Care 2011; 34 (9): 2113–5. DOI: 10.2337/dc11-0294
