QANDLI DIABETDA YURAK DISFUNKTSIYASINI SHAKLLANTIRISH VA SAKUBUTRI/VALSARTANNI QO'LLASH MEXANIZMLARI
##article.subject##:
yurak yetishmovchiligi, qandli diabet, yurakning otish fraktsiyasi, sakubitril/valsartan##article.abstract##
Yurak yetishmovchiligi (YuYe) bo'lgan bemorlarda qandli diabet (QD) bilan kasallanish darajasi, yurakning otish fraktsiyasining (OF) buzilish darajasidan qat'iy nazar, taxminan 40% ni tashkil qiladi. Ammo, bundan tashqari, diabet saqlanib qolgan va susaygan OF bilan yurak yetishmovchiligining rivojlanishi uchun kuchli mustaqil xavf omili hisoblanadi va odatda yomon prognoz bilan bog'liq. Biologik faol natriuretik peptidlar darajasini oshirish uchun neprilisin inhibitörlerinin qobiliyati ularni YuYe davolashda potentsial terapevtik yondashuvga aylantirdi. Sakubitril/valsartanni diabet bilan og'rigan yurak yetishmovchiligi bo'lgan bemorlarda qo'llashni o'rganish davom etmoqda.
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