ENERGY COVID-19 KOLLAPSIASI: DIAGNOSTIKANING YANGI MARKERLARI, DAVOLANISH ASPEKTLARI
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COVID-19, laktatning ortiqcha ishlab chiqarilishi, energiya kollapsi, Tiotriazolin##article.abstract##
COVID-19 bilan kasallangan bemorlarda prognozni baholashning mustaqil diagnostik mezonlari - bu ortiqcha ishlab chiqarish energiya ishlab chiqaruvchi tizimlarning inqirozi va energiya ishlab chiqarishning glikolitik yo'lining haddan tashqari ko'payishi natijasida yuzaga keladigan laktat dehidrogenaza, laktat darajasining dinamikasi. COVID-19 tomonidan kelib chiqqan energiya kollapsining tuzatuvchisi kuchli antioksidant xususiyatlarga ega laktat ishlatish va oksidlovchi fosforillanishni stimulyatsiya qilish uchun ko'p yo'llar bilan metabolik preparat Tiotriazolindan foydalanish bo'lishi mumkin. Yog' kislotasi metabolizmining blokatorlaridan foydalanish ularning ta'sir mexanizmining biokimyoviy xususiyatlari tufayli munozarali hisoblanadi.
Библиографические ссылки
Xong T-Y. (2020) Coronaviruses and the cardiovascular system: acute and long-term implication. European Heart Journal, ehaa231. http// doi org/10.1093/eurheart/ehaaa231. Published: 18 March.
Li B. (2020) Prevalence and impact of cardiovascular metabolic Diseases on COVID-19 in China. Clin Res Cardiol., Mar 11. doi: 10.1007/s00392-020-01626-9.
Severin E.S. (2008) Biologicheskaya himiya []. M.: OOO "Medicinskoe informacionnoe agentstvo", 364 p. (in Russian)
Valenza F. (2005) Lactat as a marker of energy failure in critically ill patients: hypothesis. Critical Care, vol. 5, no 6, pp. 588–593.
Poole R.C. (1993) Transport of lactate and other monocarboxylates across mammalian plasma membranes. American Journal of Physiology, vol. 264, pp. 761–782.
Hashimoto T., Brooks G.A. (2008) Mitochondrial lactate oxidation complex and an adaptive role for lactate production. Med Sci Sports Exerc., Mar., vol. 40(3), pp. 486–94.
(2013) Eur Heart J., vol. 34, pp. 2949–3003. doi: 10.1093 / eurheartj/eht296.
Mazur I.A. (2005) Tiotriazolin. Zaporozh'e, 146 p. (in Russian)
Netyazhenko V.Z., Mal'chevskaya T.I. (2010) Vozmozhnosti metabolicheskoj terapii v lechenii ishemicheskoj bolezni serdca: opyt dvojnogo slepogo randomizirovannogo mul'ticentrovogo issledovaniya []. Listapad, no 22 (251), pp. 1–5.
