DESFLURAN VA SEVOFLURANNING KARDIOPROTEKTIV TA'SIRLARI MEXANIZMALARI
##article.subject##:
desfluran, sevofluran, reperfuziya, postkonditsionerlash, postkonditsionerlash, reperfuziya shikastlanishi, sun’iy qon aylanish##article.abstract##
Konditsionirlangan miokard aslida ishemik reperfuziya shikastlanishini boshqarishda muhim strategiyadir. Postkonditsionirlangan anesteziya tushunchasi juda qiziq, uning ta'siri asosiy daqiqada (reperfuziya, ishemik reperfuziya shikastlanishlari boshlanganda), ushbu kardioprotektiv mexanizmlarning faollashuvi ishemik reperfuziya shikastlanishiga olib keladigan mexanizmlarni yengib chiqqanda sodir bo'ladi. Desfluran va sevofluran - bu yurak operatsiyasi paytida tez-tez ishlatiladigan uchuvchan anestetikdir. Ushbu sharh potentsial kardioprotektiv strategiya sifatida erta reperfuziya paytida qo'llaniladigan desfluran va sevofluran samaradorligiga qaratilgan. Ushbu agentlarning kardioprotektiv ta'siriga asoslangan mexanizmlar va ularning konditsionirlikni keltirib chiqarish qobiliyati batafsil muhokama qilindi, bu reaktiv kislorod turlarini yaratish va mitoxondriyalarga ta'sirini ta'kidladi. Bu, albatta, ushbu strategiyaning haqiqiy ta'sirini tasdiqlash uchun zarur bo'lgan randomizatsiyalangan klinik sinovlarni boshlash uchun asosni tiklash uchun yetarli bo'lishi mumkin.
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Advance Access published on June 9, pii: 0267659115590833
