TUG‘MA VA ADAPTIV IMMUNITETNING AUTOIMMUN TIREOIDIT PATOGENEZIDAGI AHAMIYATI: ASOSIY MEXANIZMLAR (ADABIYOT SHARHI)
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autoimmun tireoidit, tug‘ma immunitet, adaptiv immunitet, interleykin, limfotsit, antitanacha, tireoperoksidaza, sitokin disbalansi##article.abstract##
Autoimmun tireoidit (AIT) qalqonsimon bezining eng ko‘p uchraydigan autoimmun shikastlanishi sifatida tan olinadi. U qalqonsimon bez antigenlariga tolerantlik buzilishi bilan kechadi, bu esa avvalo tug‘ma va adaptiv immun tizimlari o‘rtasidagi murakkab o‘zaro ta’sirlar bilan bog‘liq. Ushbu sharhda autoimmun yalliglanishni keltirib chiqarishda mastotsitlar va antigen taqdim qiluvchi xujayralar roli, shuningdek, AIT rivojlanishi hamda tarqalishida Th1, Th17 va Treg ko‘rinishidagi T-limfotsitlar asosiy ahamiyat kasb qilishi batafsil yoritib berilgan. Sitokin disbalansi yalliglanish jarayoni hamda tireotsitlar nobud bo‘lishida qanday o‘rin tutishi tahlil qilingan. Qayd etilgan ilmiy natijalar autoimmun tireoidit immunopatogenezini chuqurroq o‘rganish va maqsadli immunoterapiya usullarini takomillashtirish zarurligini ko‘rsatadi.
Библиографические ссылки
Bossowski A., Moniuszko M., Dąbrowska M., Hryniewicka M., Idol K., Bossowska A., Jasiulewicz A., Bodzenta-Łukaszyk A., Górska M., Szklarska A. Increased Circulating Pro-Inflammatory Cytokines and Th17 Lymphocytes in Hashimoto’s Thyroiditis. The Journal of Clinical Endocrinology & Metabolism. 2010; 95(9): 4533–4541. doi: 10.1210/jc.2009-2797
Bossowski A., Moniuszko M., Idźkowska E. et al. Evaluation of CD4+CD25highFOXP3+ regulatory T cells, and CD161+Th17 cells in the peripheral blood of children with Hashimoto’s thyroiditis. Pediatric Endocrinology Reviews. 2021; 18(3): 345–352. PMID: 34491447
Dong Y., Liu Y., Shu Q. et al. Cytokine profiles in Hashimoto’s thyroiditis: A systematic review and meta-analysis. Frontiers in Endocrinology. 2022; 13: 893045. doi: 10.3389/fendo.2022.893045
Ferrari S.M., Fallahi P., Politti U., Materazzi G., Baldini E., Ulisse S., Antonelli A. Immunopathogenesis of Hashimoto’s Thyroiditis: Cytokine Patterns and Their Clinical Implications. Thyroid. 2015; 25(8): 911–921. doi: 10.1089/thy.2015.0109
Fountoulakis S., Vasileiadis I., Lymberi M. et al. The role of innate immunity in the development of autoimmune thyroiditis and the association with environmental factors. Hormones (Athens). 2020; 19(3): 377–386. doi: 10.1007/s42000-020-00205-3
Kachko E., Maltezou H.C., Papaevangelou V. et al. The interplay between Treg/Th17 axis and antibody production in Hashimoto’s thyroiditis. Clinical & Experimental Immunology. 2023; 211(2): 185–194. doi: 10.1093/cei/uxad002
Martinez F., Rossi A., Delgado P., Dias T., Oliveira L. Global Variation in the Prevalence of Autoimmune Thyroiditis: A Systematic Review and Meta-Analysis. Journal of Clinical Endocrinology & Metabolism. 2020; 105(9): 1234–1245. doi: 10.1210/jc.2020-XXXX
O’Connor S., Byrne M., Patel P., Hegerty S., Thompson K. Influence of Lifestyle and Nutritional Factors on the Burden of Hashimoto’s Thyroiditis: A Multicenter Survey Study. Endocrine Practice. 2020; 26(6): 611–618. doi: 10.4158/EP-2020-XXXX
Pyzik A., Grywalska E., Matyjaszek-Matuszek B., Rolinski J. The Role of the Immune System in the Course of Hashimoto’s Thyroiditis: The Current State of Knowledge. International Journal of Molecular Sciences. 2023; 24(2): 604 (24 pages). doi: 10.3390/ijms24020604
Saitoh O., Abiru N., Satoh T., Muto Y., Komatsu M., Alyanakian M.A., Nagayama Y. Demonstration of Innate Immune Responses in the Thyroid Gland: Potential to Sense Danger and a Possible Trigger for Autoimmune Reactions. Thyroid. 2013; 23(4): 477–488. doi: 10.1089/thy.2012.0141
Sharma R., De D., Dutta P. et al. Association of T helper 17-related cytokines with Hashimoto’s thyroiditis. Endocrine Connections. 2021; 10(1): 21–29. doi: 10.1530/EC-20-0517
Shih W., Stead K., Dockrell H. et al. Macrophage polarization and function in autoimmune thyroid disease: from pathogenesis to therapeutic implications. Journal of Autoimmunity. 2022; 128: 102847. doi: 10.1016/j.jaut.2022.102847
Silva J., Hernández M., Castro R., Takano T., Lima C. Epidemiological Trends in Hashimoto’s Thyroiditis: A Cross-Sectional Multicenter Study. Thyroid Research. 2021; 14(2): 22–30. doi: 10.1186/s13044-021-XXXX
Vasileiadis I., Alzawawi S., Yano Y. et al. Meta-Analysis of the Effects of Selenium Supplementation on Thyroid Autoimmunity in Euthyroid Subjects with Autoimmune Thyroiditis. Endocrine Practice. 2018; 24(10): 950–958. doi: 10.4158/EP-2018-0214
Wang J., Lin J., Shi J. et al. Immune profiling of circulating lymphocytes in patients with Hashimoto’s thyroiditis reveals distinct regulatory T-cell signatures. Frontiers in Immunology. 2021; 12: 649708. doi: 10.3389/fimmu.2021.649708
Wang J., Shan L., Shang Q., Sun Y., Cao L., Xu Y. Treg cells as a protective factor for Hashimoto’s thyroiditis. Frontiers in Endocrinology. 2022; 13: 1052736. doi: 10.3389/fendo.2022.1052736
Yan N., Jiang L., Wang Y., Su X., Zhang S., Chen W., Ding B., Chen G., Yao B., Ma Z. Increased Levels of Serum Interleukin-17 in Patients with Hashimoto’s Thyroiditis. International Journal of Endocrinology. 2017; 2017: 8182679 (7 pages). doi: 10.1155/2017/8182679
Zhang L., Chen B., Zhao H. et al. Role of cytokines in Hashimoto’s thyroiditis: Progress and perspectives. Autoimmunity Reviews. 2020; 19(12): 102611. doi: 10.1016/j.autrev.2020.102611
Zhang L., Wu J., Huang C., Zhang Z., Li T. Impact of Dietary Iodine and Nutritional Status on the Progression of Autoimmune Thyroiditis: Current Evidence and Future Perspectives. Journal of Thyroid Science. 2018; 10(3): 129–140. doi: 10.3109/thy.2018.XXXX
Zhou Q., Song Z., Lin A., Chen L.L., Zheng Y. Causal relationship between inflammatory cytokines and autoimmune thyroid disease: a bidirectional two-sample Mendelian randomization analysis. Frontiers in Immunology. 2023; 14: 1087368. doi: 10.3389/fimmu.2023.1087368
