HARBIY XIZMATCHILAR ORASIDA P2RY12 GENI POLIMORFIZMINI ARTERIAL GIPERTENZIYA BILAN BOG’LIQLIGI
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: P2RY12 gen polimorfizmi, harbiy xizmatchilarda arterial gipertenziya, genetik moyillik, yurak-qon tomir kasalliklari##article.abstract##
Tadqiqot natijalari shuni ko'rsatdiki, gipertoniya bilan og'rigan harbiy xizmatchilar orasida H1 / H2 heterozigot genotipi eng keng tarqalgan bo'lib, bu uning kasallik xavfi ortishi bilan bog'liqligini ko'rsatadi. Nazorat guruhida homozigot H1 / H1 genotipi ustunlik qildi, bu uning gipertenziyasi bo'lgan shaxslar oasida past chastotasida uchrashini ko'rsatdi. Korrelyatsiya tahlili heterozigot genotip bilan gipertenziyaning og'ir darajasi o'rtasidagi bog'liqlikni tasdiqladi, bu bizga kasallikning og'irligini baholash uchun muhim omil deb hisoblash imkonini beradi. H2 allelining genotiplari gipertenziya rivojlanishi yoki og'irligi bilan sezilarli bog'liqlikni ko'rsatmadi. Bu arterial gipertenziyaga sezuvchanlikning mumkin bo'lgan belgisi sifatida P2RY12 gen polimorfizmining ahamiyatini tasdiqlaydi. Shunday qilib, natijalar gipertenziyani erta tashxislash va oldini olishning yangi usullarini ishlab chiqish, shuningdek kasallikni davolash va nazorat qilish bo'yicha shaxsiylashtirilgan dasturlarni yaratish uchun asos bo'lib xizmat qilishi mumkin, bu esa harbiy xizmatchilar va aholining boshqa guruhlari o'rtasida profilaktika choralari samaradorligini sezilarli darajada oshiradi.
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