POST-COVID: EFFICACY AND SAFETY OF THIOTRIAZOLINE
Keywords:
post-covid, Thiotriazolin, efficacy, safety, quality of lifeAbstract
The use of Thiotriazoline at the outpatient stage in patients with past COVID-19 infection significantly reduces cell damage with a decrease in LDH levels in the main group from 362.5±192.9 to 221.2±98.8 U/l against the dynamics from 385.9 ±210.1 to 269.0±142.9 U/l in the control group, p=0.02, reduce ALT in the main group for a month of therapy from 69.7±35.6 U/l to 30.8± 15.5 U/l compared with the control group (from 63.7±52.7 U/l to 57.4±44.7 U/l, p=0.002).
The clinical efficacy of Thiotriazoline in patients who predominantly had pneumonia against the background of COVID-19 infection was manifested in an improvement in the integral indicators of their quality of life over a 30-day follow-up period. Significant changes were registered in achieving a higher level of health both in the analysis of the integral indicator of physical health (IPH) - 58.1±17.7 points versus 50.2±24.9 points in the control group, and in the analysis of the integral indicator of mental health (IMH) - 70.9±16.4 points in the main group versus 51.4±21.7 points in the control group, respectively, p=0.003, in the absence of complications or side effects of the drug.
References
COVID-19 Treatment Guidelines Panel. Coronavirus Disease 2019 (COVID-19) Treatment Guidelines. National Institutes of Health. Available at https://www.covid19treatmentguidelines.nih.gov/.
More than 50 long-term effects of COVID-19: a systematic review and meta-analysis / S. Lopes-Leon [et al.] // Scientific Reports. – 2021. – T. 11(16144). https://doi.org/10.1038/s41598-021-95565-8
Мареев В.Ю., Орлова Я.А., Павликова Е.П., Мацкеплишвили С.Т., Краснова Т.Н., Малахов П.С. Пульс-терапия стероидными гормонами больных с коронавирусной пневмонией (COVID-19), системным воспалением и риском венозных тромбозов и тромбоэмболий (исследование ПУТНИК) / Кардиология. – 2020. – 60(6). – С. 15-29. doi: 10/18087/cardio.2020.6.n1226.
Саливончик, Д.П. Энергетический кризис при COVID-19: диагностика и лечение / Д.П. Саливончик, Е.И. Саливончик // Рецепт. – 2020. – №5. – С. 680-693.
Metabolic perturbation associated with COVID-19 disease and SARS-CoV-2 replication / Krishnan Shuba [et al.] // Mol. Cell Proteomics. – 2021 https://doi.org/10.1016/j.mcpro.2021.100159
COVID-19: эффективность и безопасность антикоагулянтной, глюкокортикоидной и метаболической терапии / Д.П. Саливончик, И.О. Стома, Э.А. Доценко, Н.Н. Куденьчук, Е.И. Саливончик, И.А. Худяков, М.Н. Меньшакова, Е.И. Малащенко, С.Д. Саливончик, К.О. Бондарева, Е.А. Степанец, О.В. Коновалова, Е.В. Кухорева // Инфекционные болезни: новости, мнения, обучение. 2022. Т. 11, №1. С. 47-56. DOI: https.://doi.org/10/33029/2305-3496-2022-11-1-47-56
Martha JW, Wibowo A, Pranata R. Prognostic value of elevated lactate dehydrogenase in patients with COVID-19: a systematic review and meta-analysis. Postgrad Med J. 2021 doi: 10.1136/postgradmedj-2020-139542.
Терапия и госпитальная летальность пациентов с COVID-19: метаболическая эффективность Тиотриазолина / Д.П. Саливончик, И.А. Худяков, М.Н. Меньшакова, Н.В. Кравцова, С.Д. Саливончик, Е.Г. Лукашенко, Е.И. Саливончик // Медицинские новости. – 2022. – №.4. – С. 77–81.
Benefits of pulmonary rehabilitation in COVID-19: a prospective observational cohort study / R. Gloeckl, D. Leitl, I. Jarosch, T. Schneeberger, C. Nell, N. Stenzel, C. F. Vogelmeier, K.Kenn, A. R. Koczulla // ERJ Open Research. – 2021 7: 00108-2021; DOI: 10.1183/23120541.00108-2021
Тиотриазолин у пациентов со среднетяжелой клинической формой инфекции COVID-19 и высоким уровнем лактатдегидрогеназы: эффективность и безопасность / Д.П. Саливончик, И.А. Худяков, М.Н. Меньшакова, Н.И. Гавриленко, С.Д. Саливончик, О.С. Пригожая, Е.И. Саливончик // Рецепт. – 2022. – Т.25, №.1. – С. 33–47.
Саливончик, Д.П. Энергетический коллапс при COVID-19: новые маркеры диагностики, аспекты лечения / Д.П. Саливончик, Е.И. Саливончик // Журнал кардиореспираторных исследований. – 2021. – Т.2(№2). – С. 68-76. (Salivonchyk D., Salivonchyk E. Energy covid-19 collapse: new diagnostic markers, treatment aspects. Journal of cardiorespiratory research. 2021, vol.2, issue 2, pp.68-76).
Henry BM, Aggarwal G, Wong J, et al. Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity and mortality: a pooled analysis. Am J Emerg Med. 2020;38:1722–1726. doi: 10.1016/J.AJEM.2020.05.073.
Martha JW, Wibowo A, Pranata R. Prognostic value of elevated lactate dehydrogenase in patients with COVID-19: a systematic review and meta-analysis. Postgrad Med J. 2021 doi: 10.1136/postgradmedj-2020-139542.
Jenkinson, C. Short form 36 (SF-36) health survey questionnaire: normative data for adults of working age / C. Jenkinson, A. Coulter, L. Wright // Br. Med. J. – 1993. – Vol. 306. – P. 1437–1440.
The World Health Organization Quality of life assessment (WHOQOL): position paper from the World Health Organization Soc. The WHOQOL Group / Sci. Med. – 1995. – Vol. 41. – P. 1403–1409.
Recommendations (temporary) on the organization of medical care for patients with COVID-19 infection (Order of the Ministry of Health of the Republic of Belarus 11.11.2021 No. 1424).
Мазур И.А. Тиотриазолин / И.А. Мазур // Запорожье. – 2005. – 146 с.
